老年2型糖尿病患者颅内动脉粥样硬化与亚临床甲状腺功能减退的相关性研究

Analisis the correlation between intracranial atherosclerosis and subclinical hypothyroidism of elderly patients with type 2 diabetes

目的分析老年2型糖尿病患者颅内动脉粥样硬化与亚临床甲状腺功能减退的相关性,指导临床依据促甲状腺激素(TSH)预测颅内动脉粥样硬化,从而延缓或阻止动脉粥样硬化。方法选取2014年5月-2015年5月新疆医科大学附属中医医院老年2型糖尿病122例为研究对象,根据患者甲状腺功能是否正常将其分为两组,对照组83例,甲状腺功能正常;研究组39例,亚临床甲状腺功能减退。对比两组患者病情情况和生化指标。结果两组患者空腹血糖、LDL-C、HDL-C、TC、TG、血尿酸、脂蛋白(a)、D-二聚体、纤维蛋白原、同型半胱氨酸、C反应蛋白等生化指标比较差异有统计学意义(P<0.05),颅内动脉粥样硬化与TSH水平呈正相关性。结论老年2型糖尿病患者颅内动脉粥样硬化与亚临床甲状腺功能减退相关,需引起重视。

Objective To analysis the correlation between intracranial atherosclerosis and subclinical hypothyroidism of elderly patients with type 2 diabetes,and to predict intracranial atherosclerosis basis on thyroid-stimulating hormone（ TSH） with the purpose of delay or prevention for atherosclerosis. Methods From May 2014 to May2015,122 cases of type 2 diabetes mellitus elderly was selected from xinjiang medical university affiliated hospital of traditional Chinese medicine. Patients were divided into two groups according to whether their thyroid function was normal. The control group included 83 cases with normal thyroid function; the research group included 39 cases with subclinical hypothyroidism. the condition and biochemical indicators between two groups were compared.Results The difference of fasting glucose,LDL-C,HDL-C,TC,TG and blood uric acid,lipoprotein（ a）,D-dimer,fibrinogen,homocysteine,c-reactive protein and other biochemical indexes between two groups were statistically significant（ P〈0. 05）,and there was a positive correction between TSH level and intracranial atherosclerosis.Conclusion Intracranial atherosclerosis was associated with subclinical hypothyroidism among elderly patients with type 2 diabetes. This result should be paid attention.