基于紫外光谱的甲基菲罗啉NBS溴代反应研究

Research of NBS Bromination Reaction of Methyl Phenanthroline Based on UV Spectra

自由基卤代是有机合成中一类重要的反应。其中,溴代反应由于条件温和以及实现途径的多样化,研究最为深入。在目前的溴代试剂中,N-溴代丁二酰亚胺(NBS)具有成本低、操作性强等优点,广泛应用于a-氢的取代。但对于具有活泼氢的芳杂环而言,基于NBS的溴代容易受到杂原子的干扰,受反应条件的影响较大。该文以2,9-二甲基邻菲罗啉为原料,NBS为溴代试剂,合成了溴甲基邻菲罗啉。并创新性地采用紫外光谱研究了其溴代历程,对反应进行了优化,具有较高的学术与应用价值。

Halogen free radical substitution is a kind of important reactions in organic synthesis. Among them, due to the mild conditions and diversification of realization ways, bromination reaction has been studied mostly in-depth.. In the present bromination reagent, N - Bromosuccinimide （ NBS ） is widely used in replacing of α - H because of the advantages of low cost and convenient operability. But for active hydrogen in aromatic heterocyclic, bromination reaction by NBS was easily disturbed by heteroatom, and largely influenced by reaction conditions. Using 2,9-dimethyl-1,10- phenanthroline as raw material and NBS as bromination reagent, dibromomethyl phenanthroline was synthesized. On the basis, the bromination mechanism was innovatively studied by UV spectra and the reaction was optimized. The research will have high academic and application value.