肝纤维化的血清学诊断研究进展

Serologic diagnosis of liver fibrosis

肝纤维化是各种不同病因慢性肝病向终末期肝病进展的必经阶段。近年来,肝纤维化的血清学诊断因其无创性和重复性好而得到广泛的重视。肝纤维化的血清学诊断包括血清常规肝纤维化标志物、血清诊断模型、组学和基因学等方法,而两种或两种以上的血清学诊断方法和模型的联合应用将有助于提高肝纤维化及肝硬化的诊断准确性,从而试图避免临床肝活检。

Liver fibrosis is an inevitable process of chronic liver diseases with different causes which might lead to end-stage liver diseases. In recent years, the serologic diagnosis of liver fibrosis gets widely attention for its non-invasiveness and good repeatability. The serologic diagnosis of liver fibrosis includes conventional serologic markers,serologic diagnostic models, omics,genetics,and the joint application of two or more methods.