针罐结合对中重度变应性鼻炎血清Eotaxin、ICAM-1及ECP表达的影响

Influence of Acupuncture with Cupping on Serum Eotaxin,ICAM-1 and ECP Expressions of Allergic Rhinitis

目的:通过观察针罐结合对中重度变应性鼻炎患者血清Eotaxin、ICAM-1及ECP表达的影响,探讨针罐结合治疗变应性鼻炎的作用机制。方法:中重度变应性鼻炎患者70例,分为针罐结合组(36例)和药物组(34例),针罐结合组选取风池、迎香、曲池、血海、肺俞、脾俞等穴,针后背俞穴拔罐治疗;药物组采用布地奈德鼻喷雾剂联合西替利嗪片进行治疗,两组均治疗8周。分别于治疗前、治疗4周、治疗8周后采用ELISA法测定血清中Eotaxin、ICAM-1、ECP的含量。结果:针罐组治疗4周、8周后Eotaxin、ECP升高,ICAM-1降低(P<0.05或P<0.001),且ICAM-1下降较药物组明显(P<0.05)。结论:针罐结合治疗中重度变应性鼻炎可能与对Eotaxin、ICAM-1、ECP的调节作用有关。

Objective： To detect the Eotaxin,ICAM- 1 and ECP expressions of the moderate to severe allergic rhinitis patients treated with acupuncture with cupping therapy and to investigate its mechanism. Methods： Seventy cases of allergic rhinitis were divided into acupuncture group（ n = 36） and medicine group（ n = 34）. The acupuncture group received eight weeks of acupuncture with cupping and the main acupoints were Yingxiang（ LI20）,Shangxing（ GV23）,Fengchi（ GB20）,Quchi（ LI11）,Xuehai（ SP10）,Feishu（ BL13）,Geshu（ BL17）,Pishu（ BL20） and so on. The medicine group received Budesonide nasal spray and Cetirizine tablets for eight weeks. The serum levels of Eotaxin,ICAM- 1 and ECP were detected with ELISA before treatment and 4 and 8 weeks after treatment respectively. Results： After 4 or 8 weeks＇ treatment,the level of ICAM- 1 decreased while Eotaxin and ECP increased（ P 〈0. 05 or P〈0. 001） in acupuncture group and the concentration of serum ICAM- 1 was significantly lower than those in the medicine group（ P 〈0. 05）. Conclusion： Acupuncture combined with cupping therapy can significantly regulate the levels of serum Eotaxin,ICAM- 1 and ECP.