补阳还五汤对不同危险因素脑梗死患者血清MMP-9含量的影响

Buyang Huanwu Decoction on Expression of MMP-9 in Patients with Cerebral Infarction of Qi Deficiency and Blood Stasis Type

目的:观察补阳还五汤对气虚血瘀型脑梗死患者血清MMP-9表达的影响,探讨其对血管内皮细胞的保护机制。方法:选取120例脑梗死患者,根据危险因素不同分为高血压病、糖尿病两组,每组各60例,每组随机分为治疗组和对照组,即高血压治疗组和对照组各30例;糖尿病治疗组和对照组各30例。对照组均采用常规西医药治疗。治疗组在对照组治疗的基础上,加用中药补阳还五汤。治疗2周后检测血清MMP-9。结果:两组的神经功能缺损程度评分较治疗前均有明显改善,治疗组明显低于对照组(P<0.05);治疗组MMP-9水平均较对照组降低(P<0.05)。结论:补阳还五汤对不同危险因素气虚血瘀型脑梗死患者血清MMP-9表达有抑制作用,对血管内皮细胞损伤有保护作用,从而可以提高脑梗死患者临床治疗效果,降低临床发病率,减轻家庭和社会负担。

Objective： To observe the effect of Buyang Huanwu Decoction on expression of MMP- 9 in the patients with cerebral infarction of qi deficiency and blood stasis type and to explore the protective mechanism of vascular endothelial cells. Methods： 120 cases of cerebral infarction patients,according to different risk factors,were divided into hypertension group and diabetes group,each group 60 cases. Each group were randomly divided into treatment group and control group,namely hypertension treatment group and control group,30 cases in each; diabetes treatment group and control group,30 cases in each. Control group adopted the conventional western medicine treatment. Treatment group on the basis of the treatment in the control group,added Buyang Huanwu Decoction. We detected serum levels of MMP- 9 after 2weeks of treatment. Result： Neurological impairment score in both groups compared with before treatment were significantly improved,but the treatment group was significantly lower than the control group（ P 〈0. 05）. The treatment group＇s level of MMP- 9 was relatively lower than that of the control（ P 〈0. 05）. Conclusion： Buyang Huanwu Decoction for different risk factors of qi deficiency and blood stasis type of cerebral infarction patients shows inhibitory effect on the serum levels of expression of MMP- 9 and has protective effect on the vascular endothelial cell damage,which can improve the clinical therapeutic effect on patients with cerebral infarction,reduce the incidence of clinical and reduce the financial burden on the family and society.