磷酸西格列汀对2型糖尿病患者血脂的影响

Impact of sitagliptin phosphate on blood lipid of patients with type 2 diabetes

目的 观察磷酸西格列汀对2型糖尿病患者血脂的影响。方法 选取2013年7月-2014年11月我院收治的40例2型糖尿病患者,均给予磷酸西格列汀（100 mg,1次/d）治疗24周,观察治疗前后患者的空腹血糖、餐后2 h血糖、糖化血红蛋白、体重指数、血脂、血尿酸的变化。结果 治疗12周后与治疗前相比,患者的空腹及餐后血糖、糖化血红蛋白均有所降低（P〈0.05）,但体重指数、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血尿酸均无明显变化（P〉0.05）;治疗24周后与治疗前相比,患者的空腹及餐后血糖、糖化血红蛋白、总胆固醇、三酰甘油及低密度脂蛋白胆固醇均显著降低（P〈0.05）,但体重指数、高密度脂蛋白胆固醇及血尿酸无显著性变化（P〉0.05）。结论 磷酸西格列汀可有效控制2型糖尿病患者的血糖水平,同时改善血脂水平。

Objective To observe the impact of sitagliptin phosphate on blood lipid of patients with type 2 diabetic.Methods 40 patients with type 2 diabetic admitted into our hospital from July 2013 to November 2014 were selected.All patients were treated with sitagliptin phosphate（100 mg,once a day） for 24 weeks.The changes of fasting blood glucose,2 hours postprandial hyperglycemia,glycosylated hemoglobin,body weight index,blood lipid and blood uric acid in patients were observed before and after treatment. Results Compared with treatment for 12 weeks and before treatment,the level of fasting blood glucose,postprandial hyperglycemia,glycosylated hemoglobin was decreased（P〈0.05）,body weight index,total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol and blood uric acid had no obvious change（P〈0.05）.Compared with treatment for 24 weeks and before treatment,the level of fasting blood glucose,postprandial hyperglycemia,glycosylated hemoglobin,total cholesterol,triglyceride and low density lipoprotein cholesterol was obvious decreased（P〈0.05）,but body weight index,high density lipoprotein cholesterol and blood uric acid had no obvious change（P〈0.05）. Conclusion Sitagliptin phosphate can effective control blood glucose of patients with type 2 diabetic and improve blood lipid level.