非小细胞肺癌中IL-8与MCP-1的表达及其临床意义

Expression and clinical significanceof IL-8 and MCP-1 in non-small cell lung cancer

目的:探讨IL-8与MCP-1在非小细胞肺癌中的表达相关性及其与非小细胞肺癌发生发展的关系,为寻找临床治疗的新靶点提供依据。方法:选取我院自2009年6月-2014年12月收集的非小细胞肺癌组织及其对应的正常组织80例,应用免疫组化的方法检测非小细胞肺癌中IL-8与MCP-1的表达,分析其与年龄、性别、是否转移、临床分型、临床分期及病理类型等临床病理因素的关系。结果:IL-8在非小细胞肺癌中阳性表达54例(67.5%),明显高于其在正常组织中阳性表达的19例(23.8%),差异具有统计学意义(P<0.05)。MCP-1在非小细胞肺癌中阳性表达59例(73.8%),在正常组织中阳性表达12例(15.0%),两者比较差异具有统计学意义(P<0.05)。结论:IL-8及MCP-1在非小细胞肺癌中的表达明显增高,二者表达呈正相关,且均与肿瘤的分化、是否淋巴结转移及肿瘤分期有关。

Objective： To investigate the expression and clinical significance of IL - 8 and MCP - 1 in non - small cell lung cancer, to provide the basis for clinical treatment. Methods： To select 80 cases of non - small cell lung cancer tissues and their corresponding normal tissues. The expression of MCP - 1 and IL - 8 was detected by immunohistochemical method. The relationship between age, gender, clinical classification, clinical stage, pathological type were analyzed. Results ： IL - 8 in non - small cell lung cancer（ NSCLC ） positive expression was 54 （ 67.5 % ） cases, it was significantly higher than that in the normal tissue（ 19 cases ,23.8% ） ,the difference was statistically significant（ P 〈 0.05）. The expression of 59 cases of MCP - 1 in non - small cell lung cancer was positive（59 cases,73.8% ） and in normal tissue expression was positive in 12 cases （ 15.0% ）, the difference was statistically significant （ P 〈 0.05 ）. Conclusion：The expression of IL- 8 and MCP- 1 in non -small cell lung cancer was significantly higher, and ther were positively correlated. The expression of IL - 8 and MCP - 1 were related to tumor differentiation,lymph node metastasis and tumor staging.