新疆维吾尔族与汉族非小细胞肺癌EGFR突变的差异

The difference of EGFR mutation in Uygur and Han's non-small cell lung cancer in Xinjiang,China

目的:探讨新疆地区汉族及维吾尔族非小细胞肺癌(NSCLC)患者EGFR突变发生率及差异。方法:采用ARMS法对54例汉族及50例维吾尔族非小细胞肺癌组织进行EGFR突变检测,并统计两组中EGFR突变民族差异性及相关因素差异。结果:维吾尔族非小细胞肺癌组中EGFR突变率为22.0%,汉族非小细胞肺癌组中EGFR突变率为40.7%,差异有统计学意义(P<0.05)。在EGFR突变中,均以19外显子缺失、21外显子L858R突变为主,且两者在两个民族所占比率比较无统计学差异。其他相关因素比较,如病理类型、吸烟情况与性别,两组均以腺癌、不吸烟、男性患者为主,无统计学差异(P>0.05)。结论:EGFR突变率在两个民族中存在差异,其余外显子突变情况及相关因素均无差异。

Objective： To study the incidence of NSCLC of the Han and the Uygur patients with EGFR mutations. Methods ： To detect EGFR mutations in non - small cell lung cancer tissue of the Han group and the Uygur group by ARMS method. Results：In Uygur group of NSCLC EGFR mutation rate was 22.0%, the Han group NSCLC EGFR mutation rate was 40.7 % , there was statistical significance （ P 〈 0.05 ）. In EGFR mutation, all were exons 19,21, and the ratio was no statistical difference in the two groups. Other related factors, such as pathological types, smoking status, and gender, there was no statistical difference （P 〉 0.05 ）. Conclusion ： EGFR mutation rate is different in the two groups,the rest of the exou mutations situation and related factors are not different.