术前BMI对未复发乳腺癌患者总生存期的影响

The effect of preoperative BMI on overall survival in no relapsedbreast cancers

目的:探讨在可手术乳腺癌患者中,术前体脂肪健康指数(body mass index,BMI)对未复发患者总生存期(overall survival,OS)的影响。方法:回顾性分析2005年1月至2009年12月接受乳腺癌手术治疗的女性未复发患者1 498例,分别对绝经前组和绝经后组进行生存分析。结果:绝经前未复发乳腺癌患者中,TNM分期早、淋巴结转移数少、ER阳性、PR阳性的患者较TNM分期晚、淋巴结转移数多、ER阴性、PR阴性的患者OS更长(P<0.05);绝经后乳腺癌患者中,TNM分期早、淋巴结转移数少、ER阳性、Ki-67阴性较TNM分期晚、淋巴结转移数多、ER阴性、Ki-67阳性的患者OS更长;在绝经后未复发乳腺癌患者中,超重或肥胖患者较正常体重患者OS长,低体重患者OS最短。结论:对绝经后的乳腺癌幸存者而言,术前BMI<18.5kg/m2的患者总生存预后不好。足够的营养和控制体重同等重要。

Objective： To investgate the effect of preoperative body mass index（ BMI） on breast cancer overall survival（ OS） in the patients with no recrudescentand no metastatic breast cancer. Methods： To analyze the data of 1 498 patients without recurrence of breast cancer,including premenopausalgroup and postmenopausal groups for influencing factors of overall survival. Results： In postmenopausal patients with no recurrence of breast cancer,overweight or obese patients＇ OS was longer than patients in normal weight,and the low weight patients had shortest OS. Conclusion： Adequate nutrition and weight control are equally important in postmenopausal breast cancers.