脾边缘带淋巴瘤2例报道及文献复习

Splenic marginal zone lymphoma-two cases report and literature review

目的:总结脾脏边缘带淋巴瘤的临床特点、病理特征、诊断、治疗方法及预后。方法:回顾我院2例脾边缘带淋巴瘤患者的临床资料,并复习相关文献。结果:2例患者均有脾大,经脾切除后病理明确诊断。化疗后均获得完全缓解,随访5年存活。结论:脾边缘带淋巴瘤是一种相对惰性的淋巴增殖性疾病,中位生存期长,约2/3患者诊断后生存期可超过8年,因此诊断后可采用相对保守的治疗措施。

Objective： To investigate the clinical and histological characteristics,diagnosis,treatment and prognosis of splenic marginal zone lymphoma. Methods： Two cases of splenic marginal zone lymphoma were analyzed retrospectively. And the related literatures were reviewed. Results： Both patients have splenomegaly,the diagnosis was made after splenectomy. After chemical therapy,two cases acquired complete remission,after 5 years follow-up,both patients were still alive. Conclusion： Splenic marginal zone lymphoma is a low-grade lymphoma with an indolent clinical course and a long median survival time. About two thirds patients can survive more than 8 years after diagnosis. So relatively conservative therapy is appreciated.