抗焦虑药对晚期子宫内膜癌术后化疗患者生活质量的影响

The effect of anti anxiety drugs on the life quality of patients with advanced endometrial carcinoma after chemotherapy

目的:观察抗焦虑药对晚期子宫内膜癌术后化疗患者生活质量的影响,为临床治疗晚期子宫内膜癌患者提供更优的个体化治疗方案。方法:采用简单数字随机表,将120例晚期子宫内膜癌术后患者随机分为2组。治疗组60例给予化疗联合抗焦虑药治疗,对照组60例给予单纯化疗。评估并比较经不同方法治疗的患者的生活质量。结果:对照组治疗后患者的躯体、认知、情绪、社会功能与治疗前比较有所下降,差异有统计学意义(P<0.05);治疗组治疗前后各项评分比较差异无统计学意义(P>0.05)。两组治疗前后3个症状量表及5个单一项目评分比较差异无统计学意义(P>0.05)。两组治疗后疲劳、恶心呕吐、疼痛、失眠、食欲减退、呼吸困难、便秘、腹泻症状均有不同程度加重,但是治疗组在腹泻、便秘、呼吸困难方面差异无统计学意义(P>0.05)。在其它方面,两组治疗后比较差异有统计学意义(P<0.05)。结论:化疗配合抗焦虑药物治疗可以减轻单纯化疗对患者生活质量的影响。为临床晚期子宫内膜癌患者提供更优的个体化治疗方案。

Objective： To observe the effect of anti anxiety drug on the life quality of patients with advanced endometrial carcinoma after chemotherapy,and to provide better individualized treatment for patients with advanced endometrial cancer. Methods： Using simple random table numbers,120 patients with adanced endometrial cancer surgery were randomly divided into 2 groups,treatment group 60 cases received chemotherapy combined anxiolytics,60 cases as controls were treated by pure chemotherapy. Results： The body,cognition,emotion and social function of the patients after treatment decreased,and the differences were statistically significant（ P〈0. 05）. In control group,comparing after treatment,the patients＇ body,cognition,emotion,social function got worse,the difference was statistically significant（ P〈0. 05）. While the difference between scores before and after treatment was not statistically significant（ P〉0. 05）. There was no significant difference between the 3 symptoms scale and the 5 single item scores before and after treatment（ P〉0. 05）. Two groups after treatment,fatigue,nausea,vomiting,pain,insomnia,loss of appetite,dyspnea,constipation,diarrhea symptoms are aggravated by varying degrees. However,there was no significant difference in diarrhea,constipation and dyspnea between the treatment group（ P〉0. 05）. In other aspects,the difference between the two groups was statistically significant（ P〈0. 05）. Conclusion： Chemotherapy combined with anti anxiety drugs can reduce the impact of chemotherapy on the quality of life of patients,and to provide a better individualized treatment for patients with advanced endometrial cancer.