DNA双链断裂修复通路和卵巢癌的关系

The association between DNA double-strand break repair pathways and ovarian cancer

卵巢癌发生发展与DNA损伤累积引起的基因不稳定性和细胞行为异常密切相关。DNA双链断裂修复通路中最为重要的是同源重组和非同源末端连接机制以及最近发现的微同源介导的末端修复形式,能够快速准确地修复DNA双链断裂,对维持基因组稳定性起着至关重要的作用,对卵巢癌的基因诊断、基因治疗以及卵巢癌分子水平研究均有重要意义。

Ovarian cancer is closely associated with the gene instability and abnormal cell behavior caused by the accumulation of DNA damage. The most important pathways among the DNA double-strand break repair pathways is HRR,NHEJ and alt-NHEJ,which are capable of fast and accurate repair and therefore is crucial to the gene stability and is significant for the gene diagnosis,gene therapy and molecular study of ovarian cancer.