Lp—PLA2对冠状动脉介入术后再狭窄的预测价值

目的探讨脂蛋白相关磷脂酶A2（Lp—PLA2）预测冠状动脉介入术后再狭窄的价值。方法冠状动脉介入治疗的患者200例，术前检测Lp—PLA2水平，根据结果将患者分为观察组119例（Lp-PLA2≥200ng／m1）和对照组81例（Lp—PLA2〈200ng／ml）。两组患者均给予冠心病Ⅱ级预防治疗，术后对患者进行1年随访，比较两组患者再狭窄和主要心脑血管事件的发生率。结果观察组Lp-PLA 2水平显著高于对照组[（278．6±68．3）vs（178．2±36．8）ng／ml]，差异有统计学意义（P〈0．05）。通过1年随访，与对照组比较，观察组的再狭窄、死亡、非致死心肌梗死、非致死脑卒中比例明显升高[（9．24％vs6．17％），（5．88％vs3．70％），（4．20％vs2．47％），（5．04％vs3．70％）]，差异均有统计学意义（P〈0．05）。结论Lp—PLA2升高提示再狭窄和主要心脑血管事件增加，术前检测Lp-PLA2有预测价值。

Objective To explore the value of lipoprotein associated phospholipase A2 （ Lp-PLA2 ） to predict restenosis after percutaneous coronary intervention （ PCI ） . Methods 200 PCI patients were enrolled in this study, and divided into observation group （ n=119, Lp-PLA2≥200ng/mL ） and control group （n=81, Lp-PLA2〈200ng/mL ） according to the Lp-PLA2 level before operation.All patients were given medicines based on secondary prevention of coronary artery disease and follow-up regularly, observe restenosis cases and major cardiovascular events between two groups.Results The Lp-PLA2 level of the observation group was significantly higher （ 278.6 ± 68.3 vs 178.2 ± 36.8 ） ng/mL, with a significant difference （P〈0.05） .After one year follow-up, compared with the control group, the total restenosis, death, nonfatal myocardial infarction and nonfatal stroke were higher [ （ 9.24%vs6.17% ） , （5.88%vs3.70%） , （4.20%vs2.47%） , （ 5.04%vs3.70% ） ] , there were significant differences （ P〈0.05 ） . Conclusion The increase of Lp-PLA2 indicates the increased risk of restenosis and major cardiovascular events, preoperative testing Lp-PLA2 have predictive value.