血清FGF21与腹内脂肪及胰岛素抵抗相关性研究

目的探讨2型糖尿病（T2DM）患者血浆中人碱性成纤维细胞生长因子21（FGF21）水平与腹内脂肪及胰岛素抵抗的相关性。方法T2DM患者124例，按照腹内脂肪四分位法分为四组，分析腹内脂肪与FGF21和胰岛素抵抗的相关性。结果腹内脂肪越多的组别其FGF21水平也越高，且胰岛素抵抗指数越大，FGF21水平与腹内脂肪成正相关，差异有统计学意义；胰岛素抵抗不是导致FGF21升高的独立危险因素。结论T2DM患者腹内脂肪与FGF2l正相关，FGF21可能是T2DM合并肥胖发病的重要的危险因素之一。

Objective To study the relationship among plasma FGF21 level, intra-abdominal fat and insulin resistance in patients with type 2 diabetes mellitus. Methods In our hospital in patients with type 2 diabetes mellitus in intra-abdominal fat four quartiles were divided into four groups, compare the FGF21 levels and insulin resistance in the relationship, and to study the correlation between visceral fat and FGF21 and insulin resistance. Results Visceral fat more groups FGF21 levels and insulin resistance index is larger, the level of FGF21 is positively correlated with visceral fat, RZ=0.9889, the difference was statistically significant; insulin resistance is not independent risk factor of FGF21. Conclusion There is a significant positive correlation in patients with type 2 diabetes mellitus in visceral adipose tissue and FGF21, FGF21 may be one of the important risk factors of type 2 diabetes with obesity.