hs-CRP、cTnⅠ在冠心病急性冠脉综合征中临床分型和危险度分层的价值

Value of hs-CRP and cTnⅠ in clinical classification and risk stratification of acute coronary syndrome in patients with coronary artery disease

目的 探究分析高灵敏度C反应蛋白（hs-CRP）、血肌钙蛋白（cTnⅠ）在冠心病急性冠脉综合征中临床分型和危险度分层的应用价值.方法 随机选取2013年12月至2014年12月期间在我院接受治疗的90例急性冠脉综合征患者为研究对象,所选急性冠脉综合征中包括急性心梗（AMI）患者45例和不稳定性心绞痛（UA）患者45例,另选取我院健康体检者45例,并采用酶联免疫比浊法和酶联免疫吸附试验分别对三组人员进行hs-CRP、cTnⅠ的检测,对比分析hs-CRP、cTnⅠ水平检测结果对急性蔻脉综合征患者的临床诊断价值.结果 相对于不稳定心绞痛组和健康组而言,急性心梗组的血肌钙蛋白水平明显升高,对比差异有统计学意义（P＜＜0.05）,不稳定心绞痛组与健康组相比差异无明显统计学意义（P＞0.05）.高灵敏度C反应蛋白在急性心梗组、不稳定心绞痛组和对照组间的对比中,差异有统计学意义（P＜0.05）.结论 血肌钙蛋白对急性心肌梗死的临床诊断具有重要的参考价值,通过结合高灵敏度C反应蛋白的检测结果,可以对冠心病急性冠脉综合征中出现心肌梗死和不稳定心绞痛患者进行全面的临床分型和危险度分层诊断,值得临床推广应用.

Objective To explore the clinical value of high sensitivity C reactive protein （hs-CRP） and serum troponin （cTnⅠ） in the clinical classification and risk stratification of acute coronary syndrome （CHD） in patients with coronary artery disease.Methods 90 patients with acute coronary syndrome treated at our hospital from December, 2013 to December, 2014 were randomly selected as study objects;among which, 45 got acute myocardial infarction （AMI） and 45 unstable angina （UA）.45 healthy people were selected.Enzyme linked immune nephelometry and ELISA were used to detect the levels of hs-CRP and cTnⅠ in all the three groups.The levels of hs-CRP and cTnⅠ were compared and analyzed to evaluate the diagnostic value for acute coronary syndrome.Results The cTnⅠ level was obviously higher in the AMI group than in than UA group and the heathy group, with statistical differences between the AMI group and the UA group and the heathy group （P〈0.05） but no between the UA group and the healthy group （P〉0.05）.There were statistical differences in hs-CRP level between the healthy group and the AMI group and the UAP group （P〈0.05）.Conclusions Serum troponin has important reference value for the clinical diagnosis of acute myocardial infarction.The combined detection of hs-CRP and cTnⅠ can be used in the classification and risk stratification of acute coronary syndrome in patients with acute coronary heart disease occurring AMI or UA.It is worth being clinically generalized.