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B7家族成员B7-H6在肿瘤免疫中的研究进展 被引量：3

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摘要 B7-H6是B7家族新成员，能够绑定受体NKp30启动NKp30依赖的固有免疫应答。B7-H6在正常组织细胞不表达而选择性的表达在一些肿瘤细胞和恶性血液病患者的血和骨髓，属于肿瘤诱导的自身分子。在感染和肿瘤状态下，应激能够调控B7-H6的表达。共刺激分子B7-H6作为连接固有免疫与适应性免疫应答的桥梁，在肿瘤免疫治疗方面的运用前景广泛，大量针对B7-H6的肿瘤靶向治疗方法在荷瘤小鼠身上取得了显著疗效”。本文就B7-H6在肿瘤免疫方面的研究进展展开综述。
作者 陈颖 何杨 莫骏
机构地区 苏州大学附属第一医院 苏州大学唐仲英血液学研究所工程中心 苏州大学附属第一医院骨科研究所
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2015年第12期932-934,共3页 Chinese Journal of Microbiology and Immunology
基金 江苏省高校优势学科建设工程资助项目
关键词 肿瘤免疫 B7家族 家族成员 固有免疫应答 NKp30 血液病患者 共刺激分子 治疗方法
分类号 R730.3 [医药卫生—肿瘤]
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参考文献30

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同被引文献32

  • 1Bran& CS, Baratin M, Yi EC, et al. The B7 l)amily member 117- H6 is a tumor cell ligand for Ihe aclivating natural killer eell recep- lor NKp30 in humans [ J ]. J Exp Ned, 2009, 206 (7) : 1495- 1503. DOl: 10. 1084/jem. 20090681.
  • 2Malta J, Baratin M, Chiehe I,, el al. Induction of B7-H6, a lig- and fi~r lhe nalut~l killer eell-aclivating reeeplor NKp30, in inflaln- matory conditions[ J ]. Blood, 2013. 122 ( 3 ) : 394-404.
  • 3Chen Y, He Y, Mo J. The B7 famiN nlember B7-H6 in tumor hnmunilv. Chin J Microbinl lmmunol, 2015, 35 ( 12 ) : 932-934 [ J 1. DOt : I O. 3760/cnm. j. issn. 0254-5101. 2015.12. 014.
  • 4Li Y, ang Q, Mariuzza RA. Structure of tile hulnai'~ activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6[J]. J Exp Med, 2011, 208(4): 703-714. DOt: 10. 1084/jem. 20102548.
  • 5Kaitu T, Esealiere B, Gastinel LN, et al. B7-H6/NKp30 inlerac- lion: a mechanism of alerting NK cells against tmnors[J]. (2ell Mol Life Sci, 2011, 68 (21): 3531-3519. DOt: 10. 1007/ s00018-0r r -0802-7.
  • 6Pesce S, Tabellini G, Cantoni C, el al. B7-H6-mediated down- regulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape[ J]. Oncoimmunnh~gy, 2015, 4 ( 4 ) : e1001224. eCollection 2015.
  • 7Zhnu Y, Xu Y, Chen L, el al. B7-H6 expression correlates with ctlneer progression and patient's Stll3.'iva[ ill htlman ovarian cam'er [ J ]. lnl J Clin Exp Pathol, 2015, 8 (8) : 9428-9433. eColleclion 2015.
  • 8Cao G, Wang J, Zheng X, el al. Tumor lherapeulies work us stress inducers to enhance lumor sensilivilv tn naturul killer (NK) cell cytulysis by up-regulating NKp30 Ligamt BT-H6 [ J ]. J Biol Chem, 2015, 290 (50) : 29964-29973.
  • 9Schlecker E, Fiegler N, Arnold A, el aI. Metalloprotease-media- led tumor cell shedding of B7-H6, Ihe ligand ~f tile nalural killer cell-activating receplor NKp30 [ J]. ('ancer Res, 2014, 74( 13): 3429-3440.
  • 10王珂,汪丽,程苏晶,冷维春.血清CA125和CA199检测对卵巢癌诊断应用价值的探讨[J].中国实验诊断学,2014,18(4):574-576. 被引量：31

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中华微生物学和免疫学杂志
2015年 第12期

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