成都市原发性骨质疏松症患者血清25一羟维生素D水平的临床分析

The Study of Serum 25-hydroxyvitam in D Status of Patients with Primary Osteoporosis

目的调查了解成都地区原发性骨质疏松症患者体内维生素D水平的状况,为进一步更好的防治骨质疏松提供临床基础数据。方法随机选取2014年6月至2015年5月我科400例原发性骨质疏松症患者,采集其清晨空腹静脉血,用电化学发光仪(瑞士罗氏诊断)检测血中25(OH)D的水平,用SPSS13.0软件进行数据分析。结果 400例骨质疏松症患者中女性患者数量远大于男性患者,患者普遍存在着维生素D水平不足现象,其中维生素D严重缺乏和缺乏所占比例较大,男女两组在年龄和血清25(OH)D水平上差异均无统计学意义(P>0.05)。结论本研究显示成都地区骨质疏松症患者维生素D缺乏现象比较普遍,男性女性之间无明显差别。维生素D缺乏是骨质疏松发生的一个重要危险因素因此在骨质疏松的治疗中应重视维生素D水平的监测,对于维生素D缺乏的状态应给予及时、充足的补充。

Objective To investigate the serum 25-hydroxyvitamin D status of patients with primary osteoporosis in Cheng Du. Methods Four hundred primary osteoporotic patients were randomly selected from June in 2014 to May in 2015 in Cheng Du. Fastingblood samples were collected. Serum 25-hydroxyvitamin D was determined using electrochemiluminescence（ Rocher,Swiss）. The data were analyzed using a SPSS13. 0 software. Results Four hundred primary osteoporoticpatients were investigated,in which female patients were much more than male ones. Vitamin D inadequacy existed generally in primary osteoporotic patients. Among them,vitamin D deficiency and critical deficiency were in a greater ratio. There was no statistic difference in the level of vitamin D between the male and the female. Conclusion The study shows that the prevalence of vitamin D deficiency in primary osteoporotic patients in Cheng Du was common. No difference exists between males and females. This study provides certain reference for the prevention and treatment of osteoporosis.