高胆红素血症足月新生儿血清胱抑素C及β2-微球蛋白水平的临床分析

Clinical Analysis of Hyperbilirubinemia in Term Newborns Serum Cystatin C and β2-microglobulin Levels

目的分析高胆红素血症(HB)足月新生儿血清胱抑素C(Cys C)及β2-微球蛋白(β2-MG)水平的表达及意义。方法选择86例足月新生儿HB患儿为观察组,另选择60例非HB的健康新生儿为对照组。检测新生儿血清TBi L、Cys C、β2-MG、BUN、SCr指标的水平,分析不同病情程度下HB患儿各指标水平的变化情况。结果观察组患儿血清TBi L、Cys C、β2-MG指标水平均高于对照组(P<0.05)。对照组、轻、中、重度四组间的TBi L、Cys C、β2-MG比较,差异均具有统计学意义(P<0.05);而对照组、轻、中度组间BUN、SCr比较,差异均无统计学意义(P>0.05),仅重度组BUN、SCr高于对照组、轻、中度组,差异有统计学意义(P<0.05)。BUN、SCr与TBi L无相关性(P>0.05);Cys C、β2-MG与TBi L呈正相关(P<0.05)。结论血清胱抑素C及β2-微球蛋白在足月新生儿高胆红素血症早期肾功能损伤诊断中的价值优于常规BUN和SCr,可作为高胆红素血症早期肾功能损伤诊断的敏感指标。

Objective To analyze the expression and the significance of the serum cystatin C（ Cys C） and β2-microglobulin（ β2-MG） in full-term newborn with hyperbilirubinemia（ HB）. Methods 86 cases full-term newborns with HB was selected as the observation group,60 healthy newborns with non-HB as the control group. Detection of neonatal serum TBi L,level Cys C,β2-MG,BUN,SCr indicators under different severity of HB changes in children each index level. Results Observation group serum TBi L,Cys C,β2-MG index levels were higher than（ P〈0. 05）. The control group,mild,moderate,and severe TBi L between four groups,Cys C,β2-MG,the difference was statistically significant（ P〈0. 05）; while the control group,light,relatively BUN,SCr between moderate group,the differences were no statistically significant（ P〈0. 05）,only severe group BUN,SCr higher,mild to moderate group（ P〈0. 05）. BUN,SCr and TBi L no correlation（ P〈0. 05）; Cys C,β2-MG and TBi L was positively correlated（ P〈0. 05）. Conclusion Serum cystatin C and β2- microglobulin value of early renal damage hyperbilirubinemia in term newborns diagnosis of hyperlipidemia superior to conventional BUN and SCr,as early renal damage diagnosis hyperbilirubinemia sensitive indicators.