益视颗粒治疗形觉剥夺性弱视的实验研究

Experimental study on Yishi particle in treatment of deprivation amblyopia

目的观察益视颗粒对形觉剥夺性弱视的治疗作用。方法将形觉剥夺性弱视鼠随机分为正常组、弱视对照组、小剂量给药组、大剂量给药组,弱视对照组给予淀粉溶液灌胃,给药组给予益视颗粒溶液灌胃,采用闪光视觉诱发电位(F-VEP)对弱视鼠进行检测。结果药物治疗后30d,小剂量给药组F-VEP潜伏期N1、P1、N2,波峰N1-P1、P1-N2的振幅较对照组有所改善,但统计学无显著性差异(P>0.01);大剂量给药组F-VEP潜伏期N1、P1、N2,波峰N1-P1、P1-N2的振幅较对照组有明显改善,统计学存在显著性差异(P<0.01)。结论大剂量益视颗粒对弱视有一定的治疗作用,但其效果有待进一步观察。

Objective To observe the effective treatment of Yishi particle for deprivation amblyopia. Methods The deprivation amblyopia rats were randomly divided into normal group, amblyopia control group,low-dose group and large-dose group. The amblyopia control group was given starch solution to fill the stomach and the medicine group was given Yishi particle to fill the stomach, using the flash visual evoked potenfial（F-VEP） to test the amblyopia rats. Results Drug treatment after 30 days, the lowclose group,s F-VEP latency period （N1 ,P1,N2） and amplitude of wave （N1-P1 ,P1-N2） was improved than amblyopia control group,but there was no significant statistical difference （P〉0.01）. The large-dose group,s F-VEP latency period （N1 ,P1 ,N2） and amplitude of wave （N l-P1, P1-N2） was better than amblyopia control group,there was significant statistical difference between the group（P〈0.01 ）. Conclusion The large-dose Yishi particle in the treatment of amblyopia have certain effect ,but the effect remains to be seen.