地佐辛在局麻鼻内镜手术中的镇痛效果及安全性观察

Clinical Observation on Analgesic Effect and Safety of Dezocine in Endoscopic Aasal Surgery Under Local Anesthesia

目的观察地佐辛在局麻鼻内镜手术中的镇痛效果及安全性。方法 180例局麻鼻内镜手术患者随机分成地佐辛组及非地佐辛组,各90例,地佐辛组术前使用地佐辛及基础用药(阿托品及蛇毒血凝酶),非地佐辛组术前只使用基础用药(阿托品及蛇毒血凝酶),术中观察并记录患者不良反应情况,术毕行视觉模拟评分(VAS)。结果两组患者疼痛程度VAS比较,地佐辛组主要为轻度疼痛(74/90),非地佐辛组主要为中度疼痛(63/90),差异有统计学意义(P<0.05);不良反应比较,地佐辛组不良反应共13例,非地佐辛组共18例,差异无统计学意义(P>0.05)。结论地佐辛用于鼻内镜手术中镇痛,效果明显,无明显不良反应,值得临床广泛推广。

Objective To observe the analgesic effect and safety of dezocine in endoscopic nasal surgery under local anesthesia. Methods 180 patients received endoscopic nasal surgery were randomly divided into dezocine group and non-dezocine group,the dezocine group were given dezocine and basis pharmacy（Atropine and Hemocoagulase）,and the other group were given only basis pharmacy（Atropine and Hemocoagulase）. Adverse effects in all patients were observed and recorded. Visual analog scale （ VAS ） was used for rating the level of pain after operation. Results The dezocine group was mainly with mild pain （74/90）,the other group was mainly with moderate pain （63/90）. The VAS scores of both group were significant （P〈0. 05）. There were no significant（P〉0. 05） differences in the incidence of adverse effects,the dezocine group had a total of 13 cases with adverse reactions,and the other group had a total of 18 cases. Conclusions Dezocine can provide good analgesic effect in endoscopic sinus surgery,with little obvious adverse effects,which is worth clinical promotion.