乌司他丁联合血液灌流治疗百草枯中毒患儿血清学指标的影响

Effect of Ulinastatin combined with Hemoperfusion in Treatment of Paraquat Poisoning in Children with HBV Serological Markers

目的探讨乌司他丁联合血液灌流治疗百草枯中毒患儿血清学指标的影响。方法选取2013年1月至2015年6月期间,唐山妇幼保健院收治的百草枯中毒患儿80例,其中50例患儿在常规治疗的基础上给予血液灌流治疗作为对照组;30例患儿在血液灌流基础上给予乌司他丁治疗作为观察组。观察两组患儿呼吸衰竭、多脏器功能衰竭机、械通气例数。对两组患儿白细胞介素6(IL-6),肿瘤坏死因子(TNF-α)和C反应蛋白(CRP)炎性因子水平进行比较。结果观察组患儿出现呼吸衰竭、多脏器功能衰竭机、械通气例数显著少于对照组患儿,均有统计学差异(P<0.05)。在治疗第5天,观察组患儿IL-6、TNF-α和CRP水平均低于对照组,其差异有统计学意义(P<0.05)。结论乌司他丁联合血液灌流治疗百草枯中毒患儿,能够显著降低并发症发生率,降低血清炎性因子水平,临床效果满意。

Objective To investigate the effects of ulinastatin combined with hemoperfusion in treatment of paraquat poisoning in children with HBV serological markers. Method Selected January 2013 and 2015, during the month of June, Tangshan maternal and child health care hospital of paraquat poisoning 80 cases of children, of which 50 cases on the basis of routine treatment given hemoperfusion treatment as the control group; 30 cases in the blood filling flow based on given Ulinastatin treatment as observation group. Observe the two groups of patients with respiratory failure, multiple organ failure, mechanical ventilation patients. The two groups of patients with interleukin 6（IL-6） and tumor necrosis factor（TNF alpha） and C reactive protein（CRP） levels of inflammatory factors were compared. Result The observation group of patients with respiratory failure, multiple organ failure, mechanical ventilation patients were significantly less than the control group, there were statistically significant differences（P〈0.05）. At the fifth day of treatment, the levels of CRP, TNF- and IL-6 in the observation group were lower than those in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Ulinastatin combined with blood filling flow in treatment of paraquat poisoning in children, can significantly reduce the incidence of complications, reduce the level of serum inflammatory factors and clinical effect is satisfactory.