老年女性患者骨代谢指标异常与冠心病的相关性研究

Association of abnormal bone metabolism markers and risk of coronary heart disease in elder women patients

目的探讨老年女性患者血浆中骨代谢检测指标与冠心病发病关系。方法 163例患者分成3组:对照组(CON组),冠状动脉病变组(CAD组)及冠心病组(CHD组)。采集动脉粥样硬化相关危险因素及骨代谢指标值。结果与CON组比较,CAD组患者血中骨代谢指标值差异均无统计学意义(P>0.05);CHD组患者血中25-羟维生素D显著降低(P<0.05),β-胶原降解产物则显著增高(P<0.05)。而与CAD组比较,CHD组患者血中25-羟维生素D显著降低(P<0.05),β-胶原降解产物显著增高(P<0.05)。相关性分析提示,BMI、HDL-C、LDL-C和三酰甘油水平、血糖,以及25-羟维生素D与冠心病发病相关;多元回归分析结果显示LDL-C、25-羟维生素D对冠心病发病有预测价值。结论维生素D水平降低与冠心病呈正相关,可作为预测指标。

Objective To explore the correlation of bone metabolism levels and risk of coronary heart disease in eider women patients. Methods A total of 163 elder women patients were divided into three group：CON group,CAD group,and CHD group. We explored related atherosclerosis risk factors and factors related to bone metabolism. Results Compared with CON group,there was no statistical significance in CAD group in factors related to bone metabolism（P〈0.05）. In CHD group, serum 25-OH-Vitamin D significantly decreased and Q-C-terminal telopeptide of type I collagen significantly increased compared with CON group （P 〈0.05）. Compared with CAD group, the serum 25-OH-Vitamin C also significantly decreased and Q-C-terminal telopeptide of type I collagen significantly increased （P 〈 0.05）. Spearman correlation analysis showed that BMI, HDL-C, triglycerides, LDL-C, blood glucose and 25-OH-Vitamin D were correlated with coronary heart disease. With coronary heart disease as the dependent variable, the results showed lower LDL-C,25-OH-Vitamin D had independent predictive value for the risk coronary heart disease. Conclusion Lower 25-OH-Vitamin D levels in elder patients were positively correlated with coronary heart disease, and it might also be an in- dependent predictor.