透明质酸修饰的介孔二氧化硅包覆金纳米棒的制备及在肿瘤化疗-热疗联合治疗中的应用

Preparation of Hyaluronic Acid-modified Mesoporous Silica-coated Gold Nanorods and Their Application in Chemo-Photothermal Therapy of Cancer

通过在包覆了金纳米棒的介孔硅表面修饰生物相容性的透明质酸,得到了具有肿瘤靶向性的多功能药物载体.实验结果表明,透明质酸可以通过酰胺键修饰在介孔硅表面,所得药物载体可在透明质酸酶作用下实现选择性释放.该体系在近红外区域具有较高的吸收,可以在近红外光照射下实现光热转换.细胞实验结果表明,该多功能药物载体可以有效靶向CD44过量表达的乳腺癌细胞,通过CD44介导的内吞富集在肿瘤内部,结合化学药物治疗和光热治疗,显示出更高的肿瘤细胞凋亡效率.

A tumor-targeting multifunctional drug delivery system was obtained through modifying mesoporous silica-coated gold nanorods with biocompatible hyaluronic acid. The experimental results demonstrated hyaluronic acid could be modified on the surface of mesoporous silica through the formation of amide bond. The resulted drug carrier could realize enzyme-responsive drug release in the presence of hyaluronidase. UV-Vis spectra showed that the system had a high absorption in the near infrared region, thus exhibiting photothermal effect upon the near infrared light irradiation. Besides, cell experiments demonstrated the muhifunctional drug carrier could effectively target CD44 over-expressed breast cancer ceils. It could be accumulated in the tumor region through CD44 receptor mediated endocytosis. Combining chemo- and photothermal therapy resulted in improved tumor apoptosis efficiency.