生化汤加味方在稽留流产药物治疗中增效作用的临床研究及其对血清TNF-α的影响

Clinical study on the synergistic effect of Shenghua decoction additional prescription in medical abortion of missed abortion and its impact on serum TNF-α

目的探讨稽留流产常规药物流产时加用生化汤加味的临床疗效,并寻找更佳给药时间。方法将72例早期小稽留流产并住院治疗的患者随机分为3组。治疗1组于入院开始预处理时即同服生化汤加味方;治疗2组于米索前列醇用药当天开始服用中药生化汤加味方;对照组只用米非司酮联合米索前列醇药物流产。比较3组患者整体疗效、血清β-h CG、TNF-α变化。结果两治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。两治疗组用药后TNF-α值均高于对照组,差异有统计学意义(P<0.05)。结论稽留流产常规药物流产时联合生化汤加味方治疗可显著增强药流效果,缩短阴道出血时间,减少患者清宫几率,且可使患者血清TNF-α值升高。

Objective To explore the clinical effect of Shenghua decoction additional prescription in medical abortion of missed abortion,find the optimal usage time. Methods Seventy-two hospitalized missed abortion cases were randomly divided into three groups,the cases in treatment one group were treated by pretreatment and oral administration of Shenghua decoction additional prescription; the cases in treatment two group were treated by oral administration of Shenghua decoction additional prescriptionwhen using misoprostol; the cases in control group were treated by mifepristone combined with misoprostol. The overall efficacies,changes of serum β-human chorionic gonadotropin（ β-h CG） and tumor necrosis factor-α（ TNF-α） levels in the three groups were compared. Results The total effective rates in treatment one group and treatment two group were statistically significantly higher than that in control group（ P〈0. 05）. TNF-α levels after treatment in treatment one group and treatment two group were statistically significantly higher than that in control group（ P〈0. 05）. Conclusion Conventional medical abortion of missed abortion combined with Shenghua decoction additional prescriptioncan significantly improves efficacy,shortens the time of vaginal bleeding,reduces the probability of curettage,and increases serum TNF-α level.