益心舒胶囊联合比索洛尔对舒张性心衰大鼠的治疗作用

Role of Yixinshu Capsule Combined Bisoprolol Treating Diastolic Heart Failure

目的探讨益心舒胶囊联合比索洛尔治疗舒张性心力衰竭心脏血流动力学的影响。方法采用高盐喂养建立舒张功能不全性高血压大鼠模型,将24只舒张性心力衰竭大鼠随机分为3组,分别给予蒸馏水、比索洛尔水溶液、比索洛尔-益心舒胶囊水溶液治疗,共6周,观察左心室压力、左心室充盈时间、左心室舒张末期压力、等容收缩期左心室内压力上升的最大速率。结果益心舒联合比索洛尔组大鼠的左心室舒张末期压显著低于对照组和比索洛尔组,但对左心室血压的影响无统计学差异。益心舒联合比索洛尔组等容收缩期左心室内压力上升的最大速率显著高于对照组(P<0.05),而等容舒张期左心室压力下降的最大速率和左心室充盈时间(t-dp/dt_(max))在3组间未见统计学差异。结论益心舒胶囊联合比索洛尔可有效改善舒张性心力衰竭大鼠的左心室舒张功能,而不影响左心室血压。

OBJECTIVE To investigate the role of Yixinshu capsule combined bisoprolol treating diastolic heart failure（DHF） and its impact on cardiac hemodynamics. METHODS High salt feeding built diastolic dysfunction of hypertensive rats. The 24 diastolic heart failure rats were randomly divided into three groups, which were given distilled water, a solution of bisoprolol and a solution of Yixinshu capsule combined bisoprolol treatment for 6 weeks. Then left ventricular pressure, left ventricular filling time, left ventricular end-diastolic pressure, the maximum rate of isovolumic systolic, left ventricular pressure rise（dp/dt_（max）） were respectively observed. RESULTS Left ventricular end-diastolic pressure of Yixinshu capsule combined bisoprolol was significantly lower than that in the bisoprolol group and the control group（P〈0.01）, but the effect on left ventricular blood pressure was no statistically different. The maximum rate of isovolumic systolic left ventricular pressure rising of Yixinshu capsule combined bisoprolol group was significantly higher than the control group（P〈0.05）, and the maximum rate of isovolumic diastolic left ventricular pressure and the left ventricular filling time（LVSP） showed no statistical difference among the three groups. CONCLUSION Yixinshu capsule combined bisoprolol could effectively improve left ventricular blood pressure of the diastolic heart failure rats, without affecting left ventricular blood pressure.