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有无均整器模式下脊柱转移瘤立体定向放疗计划的剂量学比较 被引量:6

Dosimetric comparison of stereotactic body radiation therapy plans for spine metastasis using flattening filter free and flattening filter modes
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摘要 目的比较6MVX射线无均整器模式(FFF)和均整器模式(FF)下,脊柱转移瘤立体定向放疗(SBRT)计划的剂量学差异。方法选取9例入组患者共12处脊柱转移灶分别设计FFF—SBRT和FF—SBRT计划,比较两组计划的靶区、危及器官和正常组织剂量体积直方图(DVH)、靶区适形度(CI)、机器跳数和治疗时间的差别。结果两种模式下的计划均能满足临床治疗需要。靶区、危及器官、正常组织剂量分布相似。FFF—SBRT计划的机器跳数明显高于FF—SBRT计划(t=-5.20,P〈0.01),实际治疗时间相当于FF—SBRT计划的1/2(t=17.27,P〈0.01)。结论两种模式均能满足临床治疗需求,FFF-SBRT计划的治疗时间更短,效率更高。临床试验注册中国临床试验注册中心,ChiCTR-TRC-14004281。 Objective To compare the dosimetric difference of stereotactic body radiation therapy (SBRT) plans for spine metastasis using 6 MV X-ray flattening filter free (FFF) and flattening filter (FF) modes. Methods A total of nine previously treated patients with a total of twelve spine metastasis were retrospectively included and replanned using FFF-SBRT and FF-SBRT, respectively. The dose-volume histograms ( DVH ) , target conformity index ( CI ) , monitor unites ( MUs ) and treatment time of target volume, organs at risk and normal tissues were compared between the plans. Results Both FFF-SBRT and FF-SBRT met the clinical objectives. Dose distribution of target volume, organs at risk and normal tissues were similar. MUs of the FFF-SBRT were significantly higher than that of FF-SBRT ( t = - 5.20, P〈0. 01), while the treatment time was almost half of the latter (t = 17.27, P 〈0. 01 ). Conclusions Two plan modes are both clinically acceptable. FFF-SBRT plans are delivered in less time and with better efficiency. Trial registration Chinese clinical trial registry, ChiCTR-TRC-14004281.
出处 《中华放射医学与防护杂志》 CAS CSCD 北大核心 2016年第1期63-66,共4页 Chinese Journal of Radiological Medicine and Protection
关键词 脊柱转移瘤 立体定向放疗 无均整模式 剂量学 Spine metastasis Stereotactic body radiation therapy Flattening filter free Dosimetry
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参考文献14

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