FISH检测t（11；14）对于七例不典型套细胞淋巴瘤的诊断意义

Clinical significance of detecting t （11 ; 14 ） by fluorescence in situ hybridization for the diagnosis of 7 patients with atypical mantle cell lymphoma

目的探讨7例不典型套细胞淋巴瘤（mantlecelllymphoma，MCL）的临床特点与诊断。方法对7例因免疫表型积分为4分而误诊为慢性淋巴细胞白血病（chroniclymphocyticleukemia，CLL）的MCL患者的临床特点和诊断进行回顾。结果7例患者中浅表淋巴结肿大但难以触及者6例。所有患者均因广泛浸润骨髓被分为Ⅳ期，CLL免疫表型积分为4分，间期荧光原位杂交检测t（11；14）均为阳性。结论部分MCI。患者临床表现与CLL相似，间期荧光原位杂交检查将有助于其诊断。

Objective To study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma （MCL） . Methods The 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia （CLL） due to a score of 4 for their immunophenotypes. The clinical features and diagnosis of such patients were retrospectively analyzed. Results Six patients had superficial lymphadeneetasis but their lymph nodes could not be palpated. All 7 patients were as stage IV considering bone marrow infiltration. Scores of immunophenotype of CLL were 4, and interphase fluorescence in situ hybridization （FISH） for t（11;14） were positive in all patients. Conclusion Some MCL patients have clinicai features similar to CLL. Interphase FISH can play an important role in the diagnosis of MCL.