摘要
白介素-17(interleukin 17,IL-17)是一个重要的炎症因子,参与介导了机体的抗感染免疫及自身免疫性疾病相关的病理性炎症;此外,IL-17还与多种炎症相关的肿瘤有着密切联系。吸烟是导致肺癌的重要危险因素之一,而吸烟等因素所致的肺部慢性炎症反应伴有IL-17过表达,提示IL-17可能与肺癌的发生存在潜在联系;同时,IL-17还通过多种机制影响肺癌进展,本文对这一领域的相关研究进展进行了综述。
Interleukin 17(IL-17) is an important pro-inflammatory cytokine. It plays a critical role in mediating pathogen defense reactions, and the pathological inflammation of autoimmune diseases. IL-17 is also involved in various inflammation-related carcinogenesis. Cigarette smoking is one of the most important risk factors of lung cancer. Chronic inflammation caused by smoking and other factors is accompanied with overexpression of IL-17 within the airway, which reveals a potential relationship between IL-17 and lung carcinogenesis. Furthermore, IL-17 also plays a role in lung cancer progression via different mechanisms. In this paper, we summarized the results of current studies on IL-17 and lung carcinogenesis, as well as lung cancer progression.
出处
《中国肺癌杂志》
CAS
CSCD
北大核心
2016年第1期46-51,共6页
Chinese Journal of Lung Cancer
基金
国家自然科学基金项目(No.81172236和No.81372505)资助~~
关键词
白介素-17
炎症
肿瘤发生
肿瘤进展
肺肿瘤
Interleukin 17
Inflammation
Carcinogenesis
Cancer progression
Lung neoplasms