降钙素原在儿童感染性疾病中的临床价值

Clinical Value of Procal Citonin for Infection in Children

目的探讨血清降钙素原(PCT)在儿童感染性疾病中的临床价值。方法收集2013年6月至2013年12月儿科患者201例,其中细菌感染组76例、非细菌感染组85例,非感染组40例。进行血清降钙素原(PCT)、C反应蛋白(CRP)的水平测定,并对结果进行比较。结果以PCT≥0.5ng/ml、CRP≥5.2mg/L为阳性,细菌感染组PCT阳性率为69.74%,非细菌感染组PCT阳性率为14.11%,非感染组PCT阳性率为10%,细菌感染组与非细菌感染组、非感染组两相比较有显著差异(P<0.01);而病毒感染组与非感染组比较无差异(P>0.05)。细菌感染组CRP阳性率为73.68%,非细菌感染组CRP阳性率为47.56%,非感染组CRP阳性率为29.73%,与PCT比较,非细菌感染组CRP阳性率高于PCT阳性率(P<0.01);细菌感染组、非感染组两者阳性率比较均无差异(P>0.05)。结论血清PCT可作为儿童感染性疾病的鉴别诊断与早期检测指标,指导临床用药,控制临床滥用抗生素。

Objective To investigate the serum procalcitonin （PCT） in the clinical value of disease infection in children. Methods 201 cases of pediatric patients in collection, including bacterial infection group 76 cases, non bacterial infection group 85 cases, non infection group with 40 cases from June 2013 to December 2013. The serum procalcitonin （PCT）, C reactive protein （CRP） levels were measured, and the results were com- pared. Results PCT=0.5ng/ml, CRP =5.2mg/L is positive, the bacterial infection group the positive rate of PCT was 69.74%, non bacterial infection group, the positive rate of PCT was 14.11%, non infection group positive rate of PCT was 10%, the bacterial infection group and non bacterial infection group, non infected group comparison has the remarkable difference （P 〈 0.01）; and virus infection group and non infection group were no difference （P 〉 0.05）. Bacterial infection group, the positive rate of CRP was 73.68%, non bacterial infection group, the positive rate of CRP was 47.56%, non infection group positive rate of CRP was 29.73%, compared with PCT, non bacterial infection group positive rate of CRP was higher than that of the positive rate of PCT （P 〈 0.01）; bacterial infection group, non bacterial infection positive rate between two groups were no difference （P 〉 0.05）. Conclusion PCT can be used as a children＇s infectious diseases differential di- agnosis and early detection of indicators, to guide the clinical medication, control clinical overuse of antibiotics.