Rasmussen脑炎的病因及发病机制研究现状

Present situation of causes and pathogenesis on Rasmussen encephalitis

Rasmussen脑炎是一种起病于儿童期、病因不明的慢性神经系统疾病,以难治性癫痫、进展性肢体偏瘫及认知功能障碍为临床特点.该病常侵犯一侧脑半球,由于病因尚不清楚,病变侧大脑半球切除术是目前唯一有效的治疗方法.该病致残率高,给患者的身心带来了极大痛苦,也给家庭和社会带来了沉重负担.其病因及机理未明,发病表现多样,这使得Rasmussen脑炎的早期发现和治疗显得异常困难.目前国内尚缺少对Rasmussen脑炎病因和机制的系统介绍,本研究仅对Rasmussen脑炎的病因及其机制的研究现状进行综述,供国内同行参考.

Rasmussen encephalitis（ RE） is a chronic nervous system disease of unknown etiology that begins in childhood. It＇s characterized by intractable seizures, cognitive decline and progressive hemiparesis. It often invades one side of hemisphere.Because the pathogenesis of RE is still unclear,hemispherectomy is the only effective therapy for RE patients at present. RE brings great agony to patients,also heavy burden to their family and society with high disability. It is considerable difficult to diagnose RE in the early stage,because of its unknown etiology,pathogenesis and diverse performance. There is lack of systematical introduction of causes and mechanism about RE in the country. This article will review the etiology and mechanism of RE for researchers in related area.