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非编码RNA对部分肝切除后肝再生的调控作用 被引量：1

Regulation of noncoding RNAs in liver regeneration after partial hepatectomy
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摘要 非编码RNA主要包括微小RNA（microRNAs）和长链非编码RNA（LncRNAs）。它们以RNA的形式在转录、转录后及表观遗传学水平调控机体多种病理生理过程。近年的研究表明在肝再生过程中多种非编码RNA表达失调，进一步调节肝再生的生物学过程。本文就部分肝切除术后肝再生过程中非编码RNA的相关调控机制做一综述。 Non-coding RNAs mainly include microR-NAs and long non-coding RNAs （LncRNAs） , which work as a kind of RNA to regulate the expression of gene at the levels of transcription, post-transcription and epigenetics. Recent studies have shown that many non-coding RNAs are dysregulated during liver regeneration after partial hepatectomy. This review summa- rized the biological characteristics and regulatory mechanisms of non-coding RNAs in liver regeneration after partial hepatectomy.
作者 李翠翠 叶放发
机构地区 武汉大学中南医院武汉大学肝胆疾病研究院武汉大学移植医学中心移植医学技术湖北省重点实验室
出处 《中华肝胆外科杂志》 CAS CSCD 北大核心 2016年第1期64-67,共4页 Chinese Journal of Hepatobiliary Surgery
基金 国家自然科学基金一联合基金项目（U1403222）
关键词 非编码RNA 肝切除 肝再生 Noncoding RNAs Partial hepateetomy Liver regeneration
分类号 R657.3 [医药卫生—外科学]
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参考文献42

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中华肝胆外科杂志
2016年 第1期

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