肾素-血管紧张素系统及核因子-κB在急性胰腺炎中的共同作用

Common mechanism of renin angiotensin system and nuclear factor-kappa B in acute pancreatitis

目的急性胰腺炎（AP）作为一种常见的急腹症，以其发病急、进展快，常伴发全身炎症反应综合征（SIRS）和多器官功能障碍综合征（MODS）而闻名并引起中外学者对其治疗措施的广泛探讨。随着重症监护措施的改进，其治疗效果有所改善，但并发症率及病死率仍较高。急性胰腺炎发病机制复杂，尚存在很多争议。近期肾素-血管紧张素系统（RAS）及核因子-κB（NF—κB）对急性胰腺炎过程中的调控机制逐渐引起人们的重视，并有可能为该病的临床治疗提供重要的理论依据。本文就肾素-血管紧张素系统及核因子-κB与急性胰腺炎之间关系的研究进展进行综述。

Objective Acute pancreatitis （AP） is a common acute abdomen which is widely discussed by scientists for its fast onset, acute progress and accompanied complications including SIRS and MODS. Ahhough the therapeutic efficacy of AP was improved with the improvements in critical care, the incidence and mortality of AP remains high worldwide. The precise mechanism of AP is complicated and still controversial up to now. Recently, the regulatory mechanism of renin angiotensin system （RAS） and nuclear factor-kappa B （NF-KB） on AP has drawn attention of people. And the research could provide crucially important theoretical basis for clinical treatment. In this article, the latest research about the connection among RAS, NF-κB and AP were reviewed.