米诺环素治疗早期梅毒42例疗效观察

Curative Effect Observation of Minocycline for the Treatment of 42 Cases of Early Syphilis

目的评估米诺环素与苄星青霉素治疗早期梅毒的血清学疗效。方法采用病例对照研究,将106例早期梅毒患者分为治疗组和对照组。治疗组42例患者予口服米诺环素100mg,2次/d,疗程15d;对照组64例患者予苄星青霉素240万U分两侧臀部肌肉注射,每周1次,共3周。结果米诺环素组患者的血清学治愈率为95.24%(40/42),苄星青霉素组患者为96.88%(62/64),两组治愈率差异无统计学意义(P>0.05),治疗组和对照组分别有2例治疗失败。米诺环素组患者皮损的消退时间稍晚于苄星青霉素组,但差异无统计学意义(P>0.05)。两组患者血清固定发生率分别为19.05%(8/42)和20.31%(13/64),差异无统计学意义(P>0.05)。结论米诺环素治疗早期梅毒效果显著,是苄星青霉素治疗梅毒可靠的替代药物。

Objective To compare the serologieal results of early syphilis with treatment of minocyeline and benzathine penicillin. Methods One hundred and six primary syphilis were divided into two groups. Forty-two patients in the treatment group were treated with minocycline 100mg orally, twice daily for 15 days. The other patients as the control group, received benzathine penicillin （ a single dose of 2.4 million units intramuscularly once a week for three times）. Serological failure was defined as lack of a 4-fold drop in rapid plasma reagin titer 2 years after treatment, or a 4-fold increase in 2 years after 4-fold drop. Results The Serological cure rate of the treatment group was 95.24% （40/42） while the control group was 96. 88%. There was no significant difference between the two groups（ P 〉 0. 05 ）. There were 2 patients with serological failure in the treatment group as well as in the control group. The time of the lesions fading away was longer in the minocycline group than in the BPG group, but there was no significant difference （ P 〉 0. 05 ）. The incidence of serofast were 19.05 % （8/42）and 20. 31% （ 13/64 ） respectively in the minocycline group and in the BPG group, showing no significant difference（ P 〉0. 05 ） between the two groups. Conclusion Doxycycline which appears to be an effective agent for the treatment of early syphilis may be a reliable alternative medicine of BPG.