清热利湿益肾解毒汤治疗持续性宫颈上皮内瘤变疗效观察

Curative Observation of Using Qingre Lishi Jiedu Decoction in the Treatment of Continuous Cervical Intraepithelial Neoplasia

目的：观察清热利湿益肾解毒汤治疗持续性宫颈上皮内瘤变（CIN）的临床疗效。方法：选择我院2010年2月~2014年2月收治的97例持续性CIN患者为研究对象,采用随机数字表法分为对照组和观察组,对照组给予保妇康栓治疗,观察组采用中药清热利湿肾解毒汤治疗,比较两组免疫功能、细胞学检查（TCT）异常率、人乳头瘤病毒（HPV）阴性率、治疗效果。结果：观察组IFN-γ、TNF-α明显高于对照组,IL-10明显低于对照组（P〈0.05）;两组治疗前后IL-4比较差异无统计学意义（P〉0.05）;治疗3、6、9个月后,观察组TCT异常率明显低于对照组（P〈0.05）,HPV检测阴性率明显高于对照组（P〈0.05）;随访2年,观察组有效率（90.0%）明显高于对照组（72.3%）（P〈0.05）。结论：清热利湿益肾解毒汤有助于改善持续性CIN患者免疫功能,提高治疗效果。

Objective： To study the clinical efficacy of Qingre Lishi Jiedu Decoction in the treatment of continuous cervical intraepithelial neoplasia. Methods： 97patients with persistent CIN in our hospital from February 2010to February2014were ran- domly divided into controlled group （47cases） and observation group （50cases）, the controlled group was given Baofukang sup- pository, the observation group was given dampness kidney detoxification soup, immune function, abnormal cytology rate （TCT） and human papilloma virus （HPV） negative rate, treatment effect were compared between two groups. Results： IFN-γ, TNF-αof the observation group were significantly higher than that of the controlled group, IL-10was significantly lower than the con- trolled group （P〈0. 05） ; there was no statistical significance of IL-gbetween the two groups; 3, 6, 9months after treatment, TCT abnormal rate of the observation group was significantly lower than the controlled group （ P〈0. 05 ）, HPV testing negative rate was significantly higher than the controlled group （P〈0. 05） ; follow-up 2years , the efficient rate （90. 0% ） of the observa- tion group was significantly higher than that of the controlled group （72. 3 % ） （P〈0.05）. Conclusion： Qingre Lishi Jiedu De- coction helps to improve the immune function of patients with persistent CIN, improve the effect of treatment.