外周维生素D结合蛋白、25-羟维生素D和原发性肝细胞癌风险的关系

Association of Circulating Vitamin D Binding Protein and25-hydroxyvitamin D with the Risk of Hepatocellular Carcinoma

目的 25-羟维生素D[25(OH)D)]已被证明与原发性肝细胞癌(HCC)的发生有关,但对于维生素D结合蛋白(VDBP)在原发性肝细胞癌发生中的作用却知之甚少。作者检测了25(OH)D的主要载体维生素D结合蛋白(VDBP),研究其在25(OH)D与原发性肝细胞癌风险中的作用。方法收集146例HCC患者和249名对照组的血样,检测血浆VDBP和25(OH)D的浓度。采用logistic回归计算比值比(OR)和95%可信区间(CI),评估外周血VDBP、25(OH)D与原发性肝细胞癌的发生风险之间的关系。结果血浆VDBP浓度与HCC风险之间呈负相关;血浆25(OH)D与HCC风险呈正相关。只有在25(OH)D浓度高于中位数的人群中,VDBP升高显著,降低了HCC风险。在VDBP浓度低于中位数的人群中,高浓度的25(OH)D显著提高了HCC风险。结论高浓度的VDBP可结合更多的25(OH)D,减少游离25(OH)D的生物利用度,同时检测VDBP和25(OH)D水平对于确定维生素D与HCC风险的相关性非常重要。

Objective To investigate the role of vitamin D binding protein （VDBP）and circulating 25- hydroxyvitamin D[ 25 （OH）D ] in liver carcinogenesis. Methods The plasma DBP and 25 （OH）D levels in 146 cases of Hepatocellular carcinoma （ HCC ） patients and 249 controls were detected. The logistic regression was used to calculate the odds ratios and 95% confidence intervals for further estimation of the association of VDBP and 25（OH） D with HCC risk. Results The plasma 25 （OH）D levels was positively related with the increase risk of HCC, and plasma VDBP levels was negatively related with HCC risk. Only in men with higher plasma 25 （OH） D above the median level, high levels of VDBP were associated significantly with decreased risk of HCC. Men with higher 25 （OH） D concentrations and serum DBP below the median showed greatly elevated risk of HCC. Conclusion Higher VDBP concentrations may sequester more 25 （ OH ） D and reduce free 25 （ OH ） D bioavailability. Simultaneous examination of VDBP and 25 （ OH ） D may be important in determining the association of vitamin D with HCC risk.