血清胃蛋白酶原检测在胃相关疾病中的诊断价值

The Value of Serum Pepsinogen in Diagnosis of Various Gastric Diseases

目的探讨血清胃蛋白酶原(PG)在胃相关疾病中的诊断价值。方法收集胃镜检查阴性者87例,作为正常对照组,慢性浅表性胃炎组41例,胃溃疡组45例(其中未出血组15例,出血组30例)及胃癌组35例,利用时间分辨荧光免疫分析法检测血清中胃蛋白酶原Ⅰ(PGⅠ)和胃蛋白酶原Ⅱ(PGⅡ)的含量,并计算其比值PGⅠ/PGⅡ(PGR)。结果与正常对照组相比,胃炎组、胃溃疡组PGⅠ和PGⅡ水平明显升高(P<0.05),胃癌组PGⅠ较对照组明显降低(83.49±26.31vs 168.18±17.13),差异有统计学意义;PGR在三组中与正常对照组相比,结果明显降低(P<0.05)。PGⅠ在胃炎组、胃溃疡组(未出血组、出血组)及胃癌组的阳性率分别为41.46%,(66.67%、80.00%)和52.00%,PGⅡ在各组的阳性率分别为26.83%,(40.00%、46.67%)及0.00%,与对照组PGⅠ和PGⅡ阳性率相比,有显著性差异(P<0.05)(除胃癌组PGⅡ)。PGR在胃炎组、胃溃疡组(未出血组、出血组)及胃癌组的阳性率分别为14.63%,(26.67%、20.00%)和48.00%,与正常对照组相比,差异有统计学意义。结论血清胃蛋白酶原检测可以为胃相关疾病的诊断提供帮助,尤其PGR对胃癌的诊断具有重要意义。

Objective To explore the value of serum pepsinogen （PG） level in diagnosis of various gastric diseases. Methods 41 cases of chronic gastritis patients ,45 cases of gastric ulcer patients including 30 cases bleeding and 15 cases non-bleeding, 35 cases of gastric cancer patients and 87 cases from the negative gastroscopy as the control group were involved in this study. The serum pepsinogen I （ PG I ） and pepsinogen Ⅱ （ PG Ⅱ ） levels in all patients and controls were determined by using the method of time- resolved fluorescence, and the ratio of PG I/PG Ⅱ （PGR） was calculated. Results PG I and PG Ⅱ in chronic gastritis and gastric ulcer groups levels in gastric cancer group were decreased obviously with Compared with the control group, the contents of increased significantly significantly difference. P 〈 0.05 ）, while the PG I The positive rates of PG I in groups of gastritis, gastric ulcer （non bleeding and bleeding） and gastric cancer were 41.46%, 66.67%, 80.00% and 52.00% respectively,and meanwhile,the positive rates of PG Ⅱ in each group were 26.83%, 40.00% ,46.67% and 0.00% respectively. There was significantly differences on positive rates between those groups and controls （ P 〈 0.05 ）, except the PG Ⅱ of gastric cancer group. The positive rates of PGR in gastritis,gastric ulcer（non bleeding and bleeding）and gastric cancer groups were 14.63% ,26.67% ,20.00% and 48.00% respectively, and had significantly differences compared with controls （ P 〈 0.05 ）. Conclusion The detection of serum pepsinogen could provide some help in the diagnosis of gastric diseases, and the PGR might have great significance in the gastric cancer.