复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化43例临床疗效分析

Clinical Efficacy of 43 Cases of Alcoholic Liver Cirrhosis Treated with Compound Licorice Combined with Reduced Glutathione

目的探讨复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化临床疗效及安全性。方法将85例酒精性肝硬化患者随机分成两组,其中对照组42例,观察组43例。两组患者均给予常规治疗,对照组在常规治疗的基础上加用还原型谷胱甘肽静脉滴注治疗;观察组在对照组的基础上再加用复方甘草酸苷静脉滴注治疗,两组疗程均为3周。观察并记录治疗前后两组患者的临床体征、病症改善情况、肝功能及肝纤维化相关指标水平改变情况,并比较两组的临床疗效。结果治疗后观察组体征及病症改善情况显著优于对照组,差异有统计学意义(P<0.05);治疗后两组肝功能及肝纤维化相关指标水平均得到显著改善,且观察组改善情况显著优于对照组,差异均有统计学意义(P<0.05);观察组总有效率为93.0%,显著高于对照组(66.7%),差异有统计学意义(P<0.05);两组治疗期间均未有明显不良反应。结论复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化可有效缓解患者的临床症状,改善患者肝脏功能,抑制肝纤维化,其疗效显著、安全可靠,值得在临床上推广。

Objective To investigate the clinical efficacy and safety of compound licorice combined with reduced glutathione in the treatment of alcoholic cirrhosis. Methods 85 patients with alcoholic cirrhosis were randomly divided into two groups,42 cases in the control group, and 43 cases in the observation group. The two groups were given conventional treatment, the control group was treated with intravenous drip on the basis of conventional treatment, the observation group was treated with compound licorice and intravenous drip, and the two groups were treated with 3 weeks. The clinical signs, symptoms, liver function and liver fibrosis related indexes of two groups were observed and recorded before and after treatment, and the clinical effects of the two groups were compared. Results After treatment, the symptoms of patients in observation group were significantly better than that of control group （ P 〈 0.05 ）. The liver function and liver fibrosis indexes were significantly improved after treatment, and the observation group was The total effective rate was 66.7% in the observation significantly better than the control group （P 〈 0. 05）. group, and it was significantly higher than that in the control group （ P 〈 0.05 ）. There was no significant adverse reaction in both groups. Conclusion The compound licorice combined with reduced glutathione in the treatment of alcoholic cirrhosis can effectively relieve the clinical symptoms, improve the liver function and inhibit liver fibrosis. It is effective, safe and reliable, and worthy of clinical application.