包头地区治疗奶牛子宫内膜炎临床用药情况调查

Investigation of Clinical Medicine for Treating Cows Endometritis in Baotou Area

通过对包头地区4个奶牛场开展奶牛子宫内膜炎临床用药调查研究和病原菌的耐药性分析,分析不同诊疗方法的治疗效果。采用常规微生物学技术分离了包头地区子宫内膜炎患牛的病原菌,采用微量肉汤稀释法测定了病原菌对临床上常用抗菌药物的敏感性和耐药性,在此基础上选用敏感性高的药物进行治疗试验,比较传统治疗组与治疗试验组两者的临床疗效。传统治疗结果显示,使用13种抗菌药物治疗160例子宫内膜炎病例,其中糜宫速康(氟苯尼考)最有效,青霉素类效果最差。治疗试验结果显示,金黄色葡萄球菌、大肠杆菌、链球菌等是引起子宫内膜炎的主要病原,且分离菌株对庆大霉素、头孢噻吩等抗菌药物敏感。统计分析结果显示,治疗试验组与传统治疗组疗效差异极显著(P<0.01)。采用药敏试验筛选的敏感药物进行针对性治疗,能获得满意的治疗效果,且该方法可避免药物滥用。

In 4dairy farms located in Baotou area,clinical medicine investigation and drug resistance of pathogenic bacteria were conducted,and then curative effects of different treatment methods were analyzed.Epidemic materials were collected from diary cows infected by endometritis,from which pathogenic bacteria were isolated using conventional microbiology technologies.Broth microdilution method was used to detect the sensitivity and resistance of pathogenic bacteria to antibiotics commonly used in clinic.On this basis,the sensitive drugs were used to treat mastitis or endometritis,the clinical curative effect of traditional treatment group was compared with that of therapeutic test group.The result of traditional treatment group showed 13 antibiotics were used to treat 160 cases of endometritis,florfenicol was most effective,penicillin was most ineffective.The results of therapeutic test group showed that Staphylococcus aureus,Escherichia coli and Streptococcus were the main pathogenic bacteria of endometritis,which were sensitive to gentamicin and cefalotin,etc.The results of statistical analysis showed that the curative effect of therapeutic test group was extremely significantly different from that of traditional treatment group（P〈0.01）.Sensitive drugs screened by drug sensitive test could be used to target therapy,and obtain satisfied curative effect.Moreover,this approach could avoid antibiotic abuse.