中药治疗痛风用药规律的文献研究

Literature research on medication rule of Traditional Chinese Medicine for treatment of gout

目的:探讨中药治疗痛风的用药规律。方法:以"中药""痛风""痛风性关节炎""高尿酸血症"为检索词从中国知网和湖南中医药大学图书馆数据库中检索2005—2014年有关中药治疗痛风的期刊文献。对文献中记载的证型、方名、药名、药性、药味、归经、功效及现代药理作用进行统计。结果:共检索出符合要求的文献221篇,作者地域分布南方省份125篇、北方省份96篇。证型以湿热蕴结证最多见,其次为瘀热阻滞证。221篇文献涉及药物210味,用药总频次2251次,用药频次在10次以上的单味药59味,累计频次1947次,用药频次最高的5味药依次为牛膝、黄柏、薏苡仁、土茯苓和苍术。59味高频次药物中,药性以寒、温、平为主,药味以苦、甘、辛为主,归经以肝、脾、肺、肾、胃经为主,功效以清热、活血化瘀、利水渗湿和祛风湿为主。59味高频次药物中,涉及现代药理作用38项,主要有抑菌、镇痛、抗炎、镇静、利尿、降压、解热、抗凝等。结论:治疗痛风的中药组方中,药性以寒、温、平为主,药味以苦、甘、辛为主,功效以清热、活血化瘀、利水渗湿和祛风湿为主,多归于肝、脾、肺、肾、胃经,主要有抑菌、镇痛、抗炎、镇静、利尿、降压、解热、抗凝等作用。

Objective：To explore the medication rule of Traditional Chinese Medicine in the treatment of gout. Methods：The Boolean logical combination of traditional Chinese medicine, gout, gouty arthritis and hyperuricemia were used as index terms to retrieve all the peri- odical literatures of traditional Chinese medicine for treatment of gout included from 2005 to 2014 from China national knowledge internet and library database of Hunan University of Traditional Chinese Medicine, and then the type of SYMPTOM COMPLEX, name of prescription （TCD） , name of drug, drug properties, drug flavour, meridian distribution, clinical effect and modern pharmacological action recorded in the literatures were statistically analyzed. Results ： Two hundred and twenty - one literatures which met the requirements were searched out, and authors of 125 literatures came from southern province while authors of 96 literatures came from northern province. The most common type of SYMPTOM COMPLEX was DAMPNESS - HEAT STAGNATION, and STAGNATED HEAT STAGNATION came next. Two hundred and twenty - one literatures included 210 drugs and total frequency of drugs was 2251. There were 59 single drugs which frequency of drug was above 10 and the cumulative frequency was 1947. The top 5 drugs with high frequency of drug included twotoothed aehyranthes root, phello- dendron amurense, coix seed, glabrous greenbrier rhizome and rhizoma atractylodis in turn. For the 59 drugs with high frequency of drug, the drug properties presented mainly with cold, warm and normal ; the drug flavours presented mainly with bitter, sweet and pungent ; the meridi- an distributions presented mainly with liver meridian, spleen meridian, lung meridian, kidney meridian and stomach meridian;the clinical effects presented mainly with clearing heat, activating blood and resolving stasis, removing dampness and promoting diuresis and dispelling wind - damp ; and 38 modern pharmacological actions of the 59 drugs presented mainly with bacteriostasis, analgesia, anti - inflammatory, se- dation, diuresis, depressurization, antipyretic and anticoagulation. Conclusion： For Traditional Chinese Drugs for treatment of gout, the drug properties present mainly with cold ,warm and normal;the drug flavours present mainly with bitter, sweet and pungent;the clinical effects present mainly with clearing heat, activating blood and resolving stasis, removing dampness and promoting diuresis and dispelling wind - damp;the meridian distributions present mainly with liver meridian, spleen meridian, lung meridian, kidney meridian and stomach meridian;and the modern pharmacological actions of the drugs present mainly with bacteriostasis, analgesia, anti - inflammatory, sedation, diuresis, de- pressurization, antipyretic and anticoagulation..