胚胎着床过程中MMPs对子宫内膜重塑的作用研究进展

Research Advances in Remodeling Endometrium by Matrix Metalloproteinases in the Process of Embryo Implantation

胚胎着床是一种细胞侵袭和转移的正常生理过程,涉及细胞外基质的降解和重塑、胎盘绒毛血管的发生、子宫螺旋动脉的重建等,在基质金属蛋白酶、组织金属蛋白酶抑制剂以及其他许多因子的调控下,对子宫内膜细胞外基质进行有序地降解和重塑。对MMPs参与胚胎着床中子宫内膜重塑过程中的作用及其引起细胞外基质的变化情况进行了综述。

Embryo implantation is a normal physiology process of cell invasion and metastasis,which involves the degradation and remodeling of extracellular matrix,development of intraplacental villous vessel,rebuilding of uterine spiral arteries and etc. The extracellular matrix of endometrial is degraded and rebuilt orderly under the regulation of matrix metalloproteinases,tissue inhibitor of matrix metalloproteinase and other factors. The function of MMPs in remodeling endometrium in the process of embryo implantation and the change of extracellular matrix were reviewed.