神经肽kisspeptins与胰岛素分泌

Neuropeptide kisspeptins and insulin secretion

神经肽kisspeptins（KISSl基因编码）及其受体KISS1R[又称为G蛋白耦联受体54（GPR54）]不仅在大脑区域表达，而且存在于脂肪、肝脏、胰腺等外周组织中。新近研究发现，胰高血糖素通过cAMP-蛋白激酶A．cAMP反应元件结合蛋白通路来刺激肝脏产生神经肽kisspeptins，不同浓度的kisspeptins通过胰岛因子-1作用于GPR54对胰岛素分泌产生不同的影响。同时，kisspeptins信号受损也会导致肥胖的发生。神经肽kisspeptins可影响胰岛素的分泌，提示生殖系统轴、胰岛素分泌及肝脏之间存在一定关系，这些发现有利于进一步理解胰岛素分泌的调节机制。

Neuropeptide kisspeptins （coded by KISS1 gene） and their receptors, KISS1R [ also known as G protein-coupled receptors 54 （GPR54） ] are not only expressed in the discrete brain tissues, but also expressed in the peripheral tissues, such as fat, liver, pancreas, etc. Recent studies have indicated that glucagon stimulates the liver to produce neuropeptide kisspeptins via the cAMP-protein kinase A-cAMP-response element binding protein pathway, and different concentrations of kisspeptins act on GPR54 through islet-1 （ ISL-1 ） and have differernt effects on the secretion of insulin. Meanwhile, the damage of the kisspeptins signal can also lead to obesity. Neuropeptide kisspeptins can affect the secretion of insulin, it is suggested relationships among the axis of reproductive system, the secretion of insulin and the liver, and these findings are beneficial to further understand the regulatory mechanism of insulin secretion.