摘要
2型糖尿病是诱发阿尔茨海默病的高危因素。胰高血糖素样肽-1（GLP-1）可诱导胰岛β细胞再生和增殖，可以呈葡萄糖依赖性地促进胰岛素分泌。另外，GLP-1在治疗神经退行性病变中也有重要的作用，能降低脑内β淀粉样蛋白斑块沉积，减少氧化应激引起的神经细胞损伤，还可以调节突触的传递，增加突触的可塑性，刺激轴突生长，影响长时程增强，从而改善记忆并提高认知水平。
Type 2 diabetes has been identified as a risk factor for Alzheimer＇s disease （AD）. Glu- cagon-like peptide-1 （ GLP-1 ） can stimulate 13 cell proliferation and insulin secretion in a glucose-dependent manner. It has been shown that GLP-1 also plays important roles in the treatment of neurodegenerative dis- ease, such as reversing the detrimental effects that 13-amyloid plaque load in brain, preventing neurons from oxidative damage, modulating synaptic transmission, rescuing synaptic plasticity, stimulating neurite growth, and affecting the process of long-term potentiation. Thus it can improve memory and cognitive dysfunction.
出处
《国际内分泌代谢杂志》
2016年第1期48-51,共4页
International Journal of Endocrinology and Metabolism
