摘要
目的观察温阳平喘颗粒对慢性持续期哮喘患者血清、诱导痰嗜酸性粒细胞(EOS)、嗜酸性细胞阳离子蛋白(ECP)、ACT评分的影响。方法 75例患者随机分为3组,各25例。中药组给予温阳平喘颗粒,联合组加用舒利迭,西药组吸入舒利迭治疗,3组疗程均为4周。结果联合组总有效率92.00%、中药组总有效率88.00%、西药组总有效率88.00%,3组总有效率差别不大(P>0.05)。治疗后联合组、中药组、西药组血清EOS均较治疗前下降(均P<0.01);联合组血清ECP水平较治疗前下降(P<0.01),而中药组、西药组血清ECP较治疗前差别不大(均P>0.05);治疗后各组血清EOS、ECP指标水平差别不大(均P>0.05)。治疗后3组痰液EOS、ECP指标较治疗前降低(P<0.01);治疗后联合组EOS、ECP降低程度优于西药组(P<0.05),联合组ECP指标高于中药组(P<0.05);中药组EOS指标改善优于西药组(P<0.05),ECP指标中药组与西药组比较无明显改善(P>0.05)。各组ACT评分较治疗前均改善(P<0.01),治疗后各组组间ACT评分比较,差别不大(P>0.05)。结论温阳平喘颗粒能减轻哮喘患者气道炎症和降低气道高反应性,其机制可能与抑制嗜酸性粒细胞、阳离子蛋白分泌有关。
Objective: To study Wenyang Pingchuan Keli on induced sputum EOS,ECP and ACT in bronchial asthma. Methods: 75 patients were randomly divided into 3 groups,25 cases in each. Chinese medicine group were given the Wenyang Pingchuan Keli,the combination group added Seretide inhalation,Western medicine group with Seretide. 3 groups were treated for 4 weeks. Results: The total efficiency of the combination group was92%,Chinese medicine group 88%,Western medicine group was 88%,and there was no significant difference between groups(P〉0.05). Compared with before treatment,there was a significant difference in serum EOS and ECP index of the combination group after treatment(P〈0.05);EOS index of Chinese medicine group and Western medicine group was significantly improved(P〈0.05),while ECP index of the two had no significant difference(P〉0.05). After treatment,EOS and ECP index of the 3 groups had no significant difference(P〉0.05). Sputum EOS and ECP index of the 3 groups was significantly improved than that before treatment(P〈0.01). After treatment,compared between the combination group and Western medicine group,before and after treatment,EOS and ECP was improved significantly(P〈0.05). Compared between the combination group and the traditional Chinese medicine group,ECP index was improved significantly(P〈0.05). In the comparison of Chinese medicine group and Western medicine group,EOS index has improved significantly(P〈0.05),while ECP index showed no significant improvement(P〉0.05). Compared with before treatment,ACT scores of the three group were significantly improved(P〈0.01),while after treatment,it showed no significant difference(P〉0.05). Conclusion: Wenyang Pingchuan Keli can relieve airway inflammation in patients with asthma and reduce airway hyperresponsiveness,whose mechanism may be related to the inhibition of eosinophil cationic protein secretion.
出处
《中国中医急症》
2016年第1期10-13,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
国家中医药管理局中医药防治重大疑难疾病临床服务能力建设项目
安徽省中医特色专科(肺病科)建设项目(2014zy69
2014mzfyjs006)