益气利水法治疗急性充血性心力衰竭临床观察

Clinical Observation of Yiqi Lishui Method in Acute Congestive Heart Failure

目的观察益气利水法治疗急性充血性心力衰竭(AHF)患者的临床疗效及对其心功能的影响。方法将56例AHF患者按照随机数字表法分为两组,观察组28例采用益气利水方结合西药常规治疗,对照组28例采用西药常规治疗,观察两组治疗前后临床疗效、炎性因子水平、心脏彩超测定值(LVEDV、LVESV、LVEF)、血生化指标水平及不良反应发生情况。结果观察组临床总有效率89.29%高于对照组的64.29%;治疗后,观察组和对照组CRP、IL-6及TNF-α水平均优于治疗前,且观察组更优(P<0.05);观察组治疗后各心功能参数优于治疗前(P<0.05),对照组无明显改善;治疗后两组患者血H-FABP和BNP水平均优于治疗前,且观察组更优(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论益气利水法治疗急性充血性心力衰竭疗效确切,能明显改善患者心功能水平,降低机体炎症反应,不良反应少。

Objective： To observe clinical efficacy and effect on the cardiac function of Yiqi Lishui in treating acute congestive heart failure（AHF）. Methods： 56 cases of patients with AHF according to the random number table method were divided into two groups,observation group（28 cases） with Yiqi Lishui Decoction combined with routine western medicine for treatment,28 cases in the control group were treated with routine treatment of Western medicine. Some indicators were observed before and after treatment including the clinical efficacy,the inflammatory cytokines and the cardiac ultrasound measured value（value of LVEDV,LVESV,LVEF）,the blood biochemical parameters and the adverse reaction in two groups. Results： The clinical total effective rate in the observation group was 89.29%,higher than 64.29% of the control group. After treatment,CRP,IL-6 and TNF-αlevels were better than those before therapy in the observation group and the control group. The improvements in the observation group was more obvious than the those in control group（P〈0.05）. The cardiac function parameters after treatment in the observation group was better than it before treatment（P〈0.05）,which in the control group had no obvious improvement. The serum H-FABP and BNP levels in the two groups of patients were better than before treatment,and which in the observation group was better（P〈0.05）. The difference of the adverse effects in the two groups was not statistically significant（P〉0.05）. Conclusion： Yiqi Lishui Method in the treatment of acute congestive heart failure curative effect is exact,which can significantly improve cardiac function and reduce the inflammatory reaction,with less adverse reaction.