中老年男性血清同型半胱氨酸与代谢综合征的相关性研究

Serum homocysteine and metabolic syndrome in middle-aged and elderly men

目的:探讨基于社区人群的中老年男性血清生殖激素及同型半胱氨酸(Hcy)水平与代谢综合征(MS)及其组分之间的相互关系。方法:以农村社区人口为基础,采用整群及年龄分层抽样相结合的方法,调查中老年男性948例。采用统一的结构式问卷进行调查,测量其基本身体参数,检测其血清生殖激素、Hcy浓度和代谢指标。本研究共获得有效问卷与血清样本868份。将研究对象按照是否患有MS,划分成MS组和非MS(NMS)组,并且按照1∶1设立对照组测定其血清Hcy浓度进行研究。结果:132例诊断为MS。经非参数检验,两组间年龄无统计学差异(P>0.05),腰围(WC)、腰臀比(WHR)、体质指数(BMI)、收缩压(SBP)、舒张压(DBP)均有显著性差异(P均<0.05)。两组间实验室参数进行比较,其中总睾酮(t T)、性激素结合球蛋白(SHBG)、黄体生成素(LH)和游离睾酮指数(FTI)均有显著差异(P均<0.05),但Hcy浓度无统计学差异(P>0.05)。Hcy与MS危险因素的关联研究中,Hcy与BMI、SBP、DBP、FBG、TG、HDL-C均无相关性(P均>0.05)。MS相关因素的Logistic回归分析显示Hcy对MS无显著影响。结论:血清Hcy与MS未见显著相关性,与MS各个组分也未见显著相关性。男性血清生殖激素与MS及其各个组分存在不同程度的显著相关性。

Objective： To investigate the relationship among serum reproductive hormone levels, serum homocysteine （Hcy） levels, metabolic syndrome （MS） , and the components of MS in middle-aged and elderly males. Methods： Using the cluster and stratified sampling methods and a unified structured questionnaire, we conducted a survey among 948 men aged 40 - 80 years in the ru- ral community, measured their basic physical parameters, and obtained their reproductive hormone levels, serum Hcy concentrations, and metabolism-related indicators. We collected 868 valid questionnaires along with their serum samples, divided the subjects into an MS and a non-MS control group in a 1：1 ratio, and measured their serum Hcy concentrations. Results ： Among the subjects included, 132 were diagnosed with MS. Nonparametric tests showed statistically significant differences between the MS and non-MS groups in the waist circumference （WC）, waist-hip ratio （WHR）, body mass index （BMI）, systolic blood pressure （SBP）, and diastolic blood pressure （DBP） （P 〈 0.05 ）, but not in age （P 〉 0.05 ）. Significant differences were also observed between the two groups in the levels of serum tT, SHBG, LH, and FTI （ P 〈 0. 05 ）, hut not in the concentrations of serum Hcy（ P 〉 0.05 ）. The concentration of serum Hcy exhibited no correlation with BMI, SBP, DBP, FBG, TG, and HDL-C （P 〉 0.05 ） and had no influence on MS. Conclu- sion ： The concentration of serum Hcy is not significantly correlated with MS, nor with its components. The levels of male serum repro- ductive hormones are associated both with MS and with its components.