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邻苯二甲酸丁基苄酯的雄性生殖和发育毒性研究 被引量：8

Effect of Butyl Benzyl Phthalate on Male Reproductive and Developmental Toxicity
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摘要 邻苯二甲酸丁基苄酯(BBP)是邻苯二甲酸酯的一种,作为常用的增塑剂和溶剂,广泛应用于医疗、化工、食品、装修材料等产品,并在环境介质及人体中广泛检出.BBP被认为具有类雌激素作用,具有一定的生殖发育毒性.本文主要对BBP的代谢暴露水平、BBP及其主要代谢产物在雄性生殖发育毒性方面的研究进展进行了综述. Butyl benzyl phthalate（BBP）is one member of phthalates（PAEs）,which are used as plasticizers,solvent sand stabilizers in industry,medicine,building and consumer products.The widespread use of PAEs contributes to their omnipresent detection in the environment and human beings.BBP has been reported to be one of the homologous estrogen chemicals and it can induce reproductive and developmental toxicity.The present paper mainly reviews the exposure levels of BBP,male reproductive and developmental toxicity of BBP and its main metabolites.
作者 王晓阳 戴家银 张红霞
机构地区 中国科学院动物研究所中国科学院动物生态与保护生物学重点实验室
出处 《中国科学：生命科学》 CSCD 北大核心 2016年第1期113-119,共7页 Scientia Sinica(Vitae)
基金 国家自然科学基金(批准号:21477127)资助
关键词 邻苯二甲酸丁基苄酯 雄性生殖毒性 发育毒性 butyl benzyl phthalate（BBP） male reproductive toxicity developmental toxicity
分类号 R114 [医药卫生—卫生毒理学]
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参考文献51

  • 1Yang H J, Xie W J, Liu Q, et al. Distribution of phthalate esters in topsoil:a case study in the yellow river delta, China. Environ Monit Assess, 2013, 185:8489-8500.
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  • 3Liu W L, Shen C F, Zhang Z, et al. Distribution of phthalate esters in soil of e-waste recycling sites from Taizhou city in China. Bull Environ Contam Toxicol, 2009, 82:665-667.
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  • 5董夫银,闫杰.欧盟及美国禁用邻苯二甲酸酯的法规及其出台始末[J].检验检疫科学,2006,16(3):78-80. 被引量：47
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  • 7Piersma A H, Verhoef A, te Biesebeek J D, et al. Developmental toxicity of butyl benzyl phthalate in the rat using a multiple dose study design. Reprod Toxicol, 2000, 14:417-425.
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二级参考文献25

  • 1李文兰,杨玉楠,季宇彬,杨波.邻苯二甲酸丁基苄酯在鼠肝匀浆中的生物降解及代谢产物鉴定[J].环境科学学报,2004,24(3):498-503. 被引量：4
  • 2叶常明.环境中的邻苯二甲酸酯[J].环境科学进展,1993,1(2):36-47. 被引量：101
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  • 5PIERSMA AH, VERHOEF A, BIESEBEEK JD, et al.Developmental toxicity of butyl benzyl phthalate in the rat using a multiple dose study design[ J]. Reprod Toxicol ,2001 , 14:417 -442.
  • 6SMITH S R. Agricultural recycling of sewage and the environment [ M ]. Walliingford: CAB International,1996. 207-236.
  • 7CANTREEDS W. Comparision between the organic Fraction of Suspended Matter at a Background and an urban station[ J]. Total Environ, 1997,8( 1 ) :79 - 88.
  • 8PICARD K, LHUGUENOT J C, LAVIER-CANIVENC M C, et al. Estrogenic activity and metabolism of n - butyl benzyl phthalate in vitro: identification of the active molecule(s) [J]. Toxicol Appl Pharmacol,2001, 172:108 - 118.
  • 9VAN WEZEL A P, VAN VLAARDINGEN, POSTHUMUS R, et al. Environmental risk limits for two phthalates, with special emphasis on endocrine disruptive properties [ J ]. Ecotoxico Environ Safety, 2000,46: 3205-3214.
  • 10NAGAO T, OHTA R, MARUMO H, et al. Effect of butyl benzyl phthalate in Sprague - Dawley rats after gavage administration: a two-generation reproductive study[ J].Reprod Toxicol,2001,14:513 - 532.

共引文献185

同被引文献121

引证文献8

二级引证文献101

中国科学：生命科学
2016年 第1期

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