口腔黏膜原发恶性黑色素瘤的临床病理分析

目的对口腔黏膜原发恶性黑色素瘤的特征和疗效进行研究和探讨。方法选取2010年2月~2015年7月我院收治的口腔黏膜原发恶性黑色素瘤患者40例,采用生存分析法（Kaplan-Meier）,将患者随机分为观察组和对照组,各20例。给予对照组患者进行常规治疗,给予观察组患者在常规治疗的基础上进行辅助性化学治疗,并对患者的表现、疗效以及预后进行回顾性分析。结果观察组患者接受化疗后,患者的术后复发率为21.9%（4/20）,对照组患者进行常规治疗后,患者的术后复发率为78.1%（16/20）,明显高于观察组,差异有统计学意义（P〈0.05）。此外,接受化疗的观察组患者平均生存时间为48个月,而未接受化疗的对照组患者平均生存时间为19个月,差异有统计学意义（P〈0.05）。结论对口腔黏膜原发恶性黑色素瘤患者进行辅助化疗,一定程度上降低患者的术后复发率,延长患者的生存时间,其应用价值值得借鉴和推广。

Objective to to the oral mucosa of primary malignant melanoma of the pathological characteristics and clinical efficacy are studied and discussed. Methods In our hospital in 2010 February 2015 from Jul of the oral mucosa of primary malignant melanoma in 40 cases, using the Kaplan Meier method, patients were divided into observation group （20 cases） and control group （20 cases）, given to the control group of conventional therapy, given to the observation group on the basis of conventional treatment of adjuvant chemotherapy, and the clinical manifestations of patiems, the clinical efficacy and prognosis was retrospectively analyzed. Results Observation group patients received After treatment, the patients with postoperative recurrence rate was 21.9%（4/20）, patients of control group were treated with conventional therapy, patients with postoperative recurrence rate was 78.1% （16/20）, significantly higher than those in the observation group, the difference was statistically significant （P〈0.05）; in addition, receiving chemotherapy patients in the observation group the mean survival time for 48 months, without receiving chemotherapy in the control group, the average survival time was 19 months. The difference is statistically significant （P〈0.05）. Conclusion The oral mucosa of primary malignant melanoma patients for adjuvant chemotherapy, to reduce in a certain extent in patients with postoperative recurrence rate and prolong the survival time of patients and the clinical application value of it is worth using for reference and promotion.