摘要
目的:探讨阿托伐他汀与拜阿司匹林联用对糖尿病患者炎症因子、血管内皮功能及继发心血管事件的影响。方法:将85例2型糖尿病患者随机分为两组,分别为观察组43例,常规治疗基础上行阿托伐他汀联合拜阿司匹林治疗;对照组42例,行常规治疗。比较两组患者血脂、炎症因子、血管内皮功能变化及心血管事件。结果:(1)血脂水平的变化:治疗后观察组血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平低于对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平高于对照组(P<0.05);(2)炎症因子的变化:治疗后观察组超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)水平均显著低于对照组(P<0.05);(3)血管内皮功能的变化:治疗后观察组内皮素(ET-1)水平低于对照组,一氧化氮(NO)水平高于对照组,差异具有统计学意义(P<0.05);(4)心血管事件机率的变化:观察组继发心血管事件的机率明显低于对照组(P<0.05)。结论:阿托伐他汀与拜阿司匹林联用可明显改善糖尿病患者血脂水平、炎症因子水平、血管内皮功能,并可有效降低心血管事件机率。
Objective： To investigate the effect of atorvastatin combined with aspirin on flammatory factors, endothelial function and the cardiovascular complications with diabetic patients. Methods： A total of 85 type 2 diabetic patients were ran- domly divided into observation group （43 cases） and control group （42 cases）. All patients recieved routine treatment of hypo- glycemic drug, while patients in observation group also received atorvastatin and aspirin. Levels of blood lipid, flammatory fac- tors （hs-CRP, TNF-α, IL-6） endothelial functlon（ET 1,NO）, and incidence of cardiovascular complications were tested and compared. Results： Significant difference in blood lipid was found between two groups after treatment, TC, TG, LDL-C were significantly lower in observation group, but HDL-C was significantly higher in observation group （P〈0.05）. Flammatoryfactors （hs-CRP, TNF-a, IL-6） levels of the observation group decreased significantly after treatment （P〈0.05）; ET 1 level decreased significantly but NO level increased significantly in the observation group after treatment （P〈0.05）; Incidence of cardiovascular complications in observation group was lower than control group. Conclusion： Atorvastatin combined with aspirin treatment shows reliable curative effect in diabetic patients, which can regulate flammatory factors, endothelial function and in- cidence of cardiovascular events.
出处
《海南医学院学报》
CAS
2016年第5期441-443,446,共4页
Journal of Hainan Medical University
基金
湖北省自然科学基金资助项目(2012CDA177)~~
