光动力疗法联合Lucentis玻璃体腔注射治疗脉络膜新生血管疾病的疗效评估

Efficacy evaluation of photodynamic therapy combined with intravitreal injection of Lucentis therapy for choroidal neovascularization

目的：分析光动力疗法联合Lucentis玻璃体腔注射治疗脉络膜新生血管疾病（CNV）的疗效。方法：选取2013年8月～2014年8月在我院接受住院治疗的82例CNV患者作为研究对象，按照随机数表法将所有入组患者分为：对照纽（接受光动力疗法治疗）及观察组（接受光动力疗法联合Lucentis玻璃体腔注射治疗），每组各41例。比较两组最佳矫正视力、眼压及视网膜黄斑中央厚度、视野平均敏感度等差异。结果：观察组接受治疗后的视力提高比例显著高于对照组，视力下降比例低于对照组（P〈0．05）；眼压及视网膜黄斑中央厚度均明显小于对照组（P〈0．05）；10。及30。视野平均敏感度均高于对照组（P〈0．05）。结论：光动力疗法联合Lucentis玻璃体腔注射治疗可以有效提升CNV患者的视力及视敏度，降低眼压及视网膜黄斑中央厚度，是一种理想的治疗方式。

Objective： To analyze the efficacy of photodynamic therapy combined with intravitreal injection of Lucentis therapy for ehoroidal neovascularization （CNV）. Methods： A total of 82 cases of patients with CNV admitted to our hospital from August 2013 to August 2014 were selected as research subjects. According to random number table method, all enrolled patients were divided into control group （receiving photodynamic therapy only） and observation group （receiving photodynamie therapy combined with intravitreal injection of Lueentis therapy）, with 41 cases in each. Differences in best-corrected visual a- cuity, intraocular pressure and central macular thickness, mean sensitivity of visual field and so on in two groups were com- pared. Results： After treatment, visual acuity improvement ratio of observation group was significantly higher than that of con- trol group and visual acuity decrease ratio was lower than that of control group （P〈0.05）; intraocular pressure and central macular thickness were significantly less than those of control group （P〈0.05）; mean sensitivity of 10° and 30° visual field was higher than that of control group （P〈0.05）. Conclusions： Photodynamic therapy combined with intravitreal injection of Lucentis therapy can effectively improve vision and visual acuity of patients with CNV and meanwhile reduce intraocular pres-sure and central macular thickness, which makes it an ideal treatment method.