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乳腺癌中转录因子Twist表达及生物学效应的研究进展 被引量：2

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摘要 Twist基因所编码的蛋白是一种碱性螺旋-环-螺旋（basichelix-loop-helix）类型的转录因子，不仅在胚胎发育过程中发挥了重要作用，还参与了恶性肿瘤的发生和发展。乳腺癌是女性发病率最高的恶性肿瘤，临床上主要进行手术切除、放疗、靶向治疗、内分泌治疗等综合治疗，对患者的预后具有显著的改善效果。
作者 覃天
机构地区 广西科技大学二附院乳腺外科
出处 《海南医学院学报》 CAS 2016年第5期518-520,共3页 Journal of Hainan Medical University
基金 广西区妇女儿童关爱专项基金(GXFNK20140317)
关键词 乳腺癌 TWIST 转录因子 增殖 侵袭 上皮-间质转化 综述文献
分类号 R737.9 [医药卫生—肿瘤]
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参考文献18

  • 1Wushou A, Hou J, Zhao YJ, et al. Twist-1 up regulation in carcinoma correlates to poor survival [J]. Int J Mol Sei, 2014, 15(12) :21621-21630.
  • 2Lee KW, Yeo SY, Sung CO, et aL Twistl is a key regulator of cancer-associated fibroblasts [J], Cancer Res, Z015, 75(1) :78- 85.
  • 3Huang J, Ang L, Liu MQ, et al. Serum and tissue expression of gelatinase and Twist in breast cancer [J]. Eur Rev Med Pharmacol Scl, 2014, 18(18):2662-2669.
  • 4王伟,刘建波,李会荣,刘明博,李白羽,王跃伟.TWIST和雌激素受体α在乳腺癌组织中的表达及对预后的影响[J].中国现代医学杂志,2015,25(21):11-16. 被引量：9
  • 5Cheng GZ, Chan J, Wang Q, et al. Twist transcriptionally up- regulates AKT2 in breast cancer cells leading to increased mi- gration, invasion, and resistance to paclitaxeI [J]. Cancer Res, 2007, 67(5): 1979-1987.
  • 6Vesuna F, Lisok A, Kimble B, et al. Twist contributes to hor- mone resistance in breast cancer by downregulating estrogen re- ceptor-a [J]. Oncogene, 2012, 31(27):3223-3234.
  • 7Kwilas AR, Ardiani A, Dirmeier U, et al. A poxviral-based cancer vaccine the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model[J]. Oneotarget, 2015, 6(29):28194-28210.
  • 8Ranganathan S, Halagowder D, Sivasithambaram ND. Querce- tin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells [J]. PLoS One, 2015, 10(10):e0141370.
  • 9Yang L, Hou Y, Yuan J, et al. Twist promotes reprogram- ruing of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways [J]. Oncotarget, 2015, 6(28) :25755-25769.
  • 10Zhang YQ, Wei XL, Liang YK, et al. Over-Expressed Twist Associates with Markers of Epithelial Mesenehymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt Activation [J]. PLoSOne, 2015, 10(8):e0135851.

二级参考文献24

  • 1Liu A N, Zhu Z H, Chang S J, et al. Twist expression associated with the epithelial-mesenchymal transition in gastric cancer[ J]. Mol Cell Biochem, 2012, 367(1/2) : 195 -203.
  • 2Visvader J E, Lindeman G J. Cancer stem cells in ：lid tumours: ac- cumulating evidence and unresolved questions[J]. Nat Rev Cancer, 2008, 8(10): 755-768.
  • 3Pallini R, Ricci-Vitiani L, Banna G L, et al. Cancer stem cell analy- sis and clinical outcome in patients with glioblastoma muhiforme[ J]. Clin Cancer Res, 2008, 14(24) : 8205 -8212.
  • 4Mani S A, Guo W, Liao M J, et al. The epithelial-mesenchymal tran- sition generates cells with properties of stem cells[ J ]. Cell, 2008, 133 (4) : 704 -715.
  • 5Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic b：ast cancer cells with stem/progenitor cell properties [J]. Cancer Res, 2005, 65( 13): 5506-5511.
  • 6Vesuna F, Lisok A, Kimble B, et al. Twist modulates breast cancer stem cells by tran：riptional regulation of CD24 expression [ J ]. Nco- plasia, 2009, 11(12): 1318-1328.
  • 7Shaw F L, Harrison H, Spence K, et al. A detailed mammosphere as- say protocol for the quantification of breast stem cell activity [ J ]. J Mammary Gland Biol Neoplasia, 2012, 17(2) : 1 11 - 117.
  • 8Yang J, Mani S A, Donaher J L, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis [ J ]. Cell, 2004, 117(7) : 927 -939.
  • 9Kurrey N K, Jalgaonkar S P, Joglekar A V, et al. Snail and slug me- diate radioresistance and ehemoresistance by antagonizing p53-media- ted apoptosis and acquiring a stem-like phenotype in ovarian caneer cells[J]. Stem Cells, 2009, 27(9) : 2059 -2068.
  • 10Yang M H, Hsu D S, Wang H W, et al. Broil is essential in Twistl- induced epithelial-mesenchymal transition[ J ]. Nat Cell Biol, 2010, 12(10) : 982 -992.

共引文献12

同被引文献23

引证文献2

二级引证文献6

海南医学院学报
2016年 第5期

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